| 产品: | SEMA4D 抗体 |
| 货号: | DF8058 |
| 描述: | Rabbit polyclonal antibody to SEMA4D |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Sheep, Rabbit, Dog |
| 分子量: | 96 kDa; 96kD(Calculated). |
| 蛋白号: | Q92854 |
| RRID: | AB_2841414 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8058, RRID:AB_2841414.
展开/折叠
A8; BB 18; BB18; CD 100; CD100; CD100 antigen; Coll 4; COLL4; Collapsin 4; Collapsin4; GR3; Leukocyte activation antigen CD100; M sema G; MSEMA; SEM4D_HUMAN; Sema 4d; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4D; Sema H; SEMA J; Sema4d; Semacl 2; Semacl2; SemaH; SEMAJ; Semaphorin 4D; Semaphorin C like 2; Semaphorin H; Semaphorin J; Semaphorin-4D; Semaphorin4D; SemaphorinJ; Semcl 2; Semcl2;
抗原和靶标
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
- Q92854 SEM4D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQLHSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKSDFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLSARDKPFDVKCELKFADSDADGD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92854 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| N49 | N-Glycosylation | Uniprot | |
| N77 | N-Glycosylation | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| N139 | N-Glycosylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| N191 | N-Glycosylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K276 | Acetylation | Uniprot | |
| N329 | N-Glycosylation | Uniprot | |
| N379 | N-Glycosylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| N419 | N-Glycosylation | Uniprot | |
| K505 | Ubiquitination | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| Y561 | Phosphorylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| T657 | O-Glycosylation | Uniprot | |
| T663 | O-Glycosylation | Uniprot | |
| S666 | O-Glycosylation | Uniprot | |
| T670 | O-Glycosylation | Uniprot | |
| T716 | O-Glycosylation | Uniprot | |
| S722 | O-Glycosylation | Uniprot | |
| Y727 | Phosphorylation | Uniprot | |
| S769 | Phosphorylation | Uniprot | |
| S788 | Phosphorylation | Uniprot | |
| K790 | Ubiquitination | Uniprot | |
| S798 | Phosphorylation | Uniprot | |
| K808 | Ubiquitination | Uniprot | |
| Y815 | Phosphorylation | Uniprot | |
| T817 | Phosphorylation | Uniprot | |
| K825 | Ubiquitination | Uniprot | |
| S833 | Phosphorylation | Uniprot | |
| S840 | Phosphorylation | Uniprot | |
| S857 | Phosphorylation | Uniprot |
研究背景
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.
Cell membrane>Single-pass type I membrane protein.
Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Homodimer. Interacts with PLXNB2 (By similarity). Interacts with PLXNB1.
Belongs to the semaphorin family.
研究领域
· Organismal Systems > Development > Axon guidance. (View pathway)
限制条款
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