| 产品: | CMTM4 抗体 |
| 货号: | AF9042 |
| 描述: | Rabbit polyclonal antibody to CMTM4 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Chicken |
| 分子量: | 25kDa; 26kD(Calculated). |
| 蛋白号: | Q8IZR5 |
| RRID: | AB_2843233 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9042, RRID:AB_2843233.
展开/折叠
Chemokine like factor super family 4; Chemokine-like factor superfamily member 4; CKLF-like MARVEL transmembrane domain containing 4; CKLF4; CKLFSF4; CMTM4;
抗原和靶标
- Q8IZR5 CKLF4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFFIASIVLAALNHRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTFSYSTNVTVRKKSPTNLLSLNHWQLA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8IZR5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S25 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| Y187 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| T208 | Phosphorylation | Uniprot |
研究背景
Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
Membrane>Multi-pass membrane protein.
Highly expressed in testis and prostate.
Interacts with PD-L1/CD274 and CMTM6.
Belongs to the chemokine-like factor family.
限制条款
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