| 产品: | BANP 抗体 |
| 货号: | DF12849 |
| 描述: | Rabbit polyclonal antibody to BANP |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
| 分子量: | 56 kDa; 56kD(Calculated). |
| 蛋白号: | Q8N9N5 |
| RRID: | AB_2845810 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12849, RRID:AB_2845810.
展开/折叠
AAH09424; Banp; BANP_HUMAN; BEN domain-containing protein 1; BEND1; BTG3 associated nuclear protein isoform a; Btg3-associated nuclear protein; DKFZp761H172; FLJ 10177; FLJ 20538; FLJ10177; FLJ20538; Protein BANP; Scaffold/Matrix associated region 1; Scaffold/matrix-associated region-1-binding protein; SMAR 1; SMAR1; SMARBP 1; SMARBP1;
抗原和靶标
- Q8N9N5 BANP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMSEHDLADVVQIAVEDLSPDHPVVLENHVVTDEDEPALKRQRLEINCQDPSIKTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENVISNAVPGRRQNTIVVKVPGQEDSHHEDGESGSEASDSVSSCGQAGSQSIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPNSSSYCPSEPMMSTPPPASELPQPQPQPQALHYALANAQQVQIHQIGEDGQVQVGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQLLEATRIPCLLAPSVFKASSGQVLQGAQLIAVASSDPAAAGVDGSPLQGSDIQVQYVQLAPVSDHTAGAQTAEALQPTLQPEMQLEHGAIQIQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8N9N5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S19 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| Y287 | Phosphorylation | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| R324 | Methylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| T337 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| T352 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
研究背景
Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity).
Nucleus.
Down-regulated in breast cancer cell lines.
Interacts with TP53 and CUX1/CDP (By similarity). Interacts with HDAC1. Part of a corepressor complex containing BANP, HDAC1, SIN3A, SIN3B, RBL1 and RBL2.
Belongs to the BANP/SMAR1 family.
限制条款
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