| 产品: | CDC2L1 抗体 |
| 货号: | DF3118 |
| 描述: | Rabbit polyclonal antibody to CDC2L1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Xenopus |
| 分子量: | 92 KD; 93kD(Calculated). |
| 蛋白号: | P21127 |
| RRID: | AB_2835495 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3118, RRID:AB_2835495.
展开/折叠
CDC2L1; CDK11; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11B; CLK 1; EC=2.7.11.22; Galactosyltransferase associated protein kinase p58/GTA; ITSLRE serine/threonine protein kinase CDC2L1; p58 CLK 1; PITSLREA; PK58;
抗原和靶标
- P21127 CD11B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P21127 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Sumoylation | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| K20 | Sumoylation | Uniprot | |
| K20 | Ubiquitination | Uniprot | |
| K29 | Sumoylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| Y67 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot | |
| K135 | Acetylation | Uniprot | |
| S212 | Phosphorylation | Uniprot | |
| Y222 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| K225 | Acetylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| K266 | Sumoylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| T395 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| Y406 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S414 | Phosphorylation | Uniprot | |
| K419 | Sumoylation | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| T448 | Phosphorylation | Uniprot | |
| Y449 | Phosphorylation | Uniprot | |
| Y453 | Phosphorylation | Uniprot | |
| K456 | Acetylation | Uniprot | |
| K458 | Acetylation | Uniprot | |
| K459 | Acetylation | Uniprot | |
| K459 | Sumoylation | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K467 | Acetylation | Uniprot | |
| K467 | Sumoylation | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K475 | Ubiquitination | Uniprot | |
| S482 | Phosphorylation | Uniprot | |
| T488 | Phosphorylation | Uniprot | |
| K491 | Sumoylation | Uniprot | |
| K491 | Ubiquitination | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| K564 | Sumoylation | Uniprot | |
| K564 | Ubiquitination | Uniprot | |
| K577 | Ubiquitination | Uniprot | |
| Y587 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y594 | Phosphorylation | Uniprot | |
| T595 | Phosphorylation | P50613 (CDK7) | Uniprot |
| T600 | Phosphorylation | Uniprot | |
| K641 | Sumoylation | Uniprot | |
| K641 | Ubiquitination | Uniprot | |
| K649 | Sumoylation | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| K652 | Sumoylation | Uniprot | |
| K652 | Ubiquitination | Uniprot | |
| K660 | Ubiquitination | Uniprot | |
| K672 | Ubiquitination | Uniprot | |
| K673 | Sumoylation | Uniprot | |
| K673 | Ubiquitination | Uniprot | |
| T675 | Phosphorylation | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| K719 | Sumoylation | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| T726 | Phosphorylation | Q9UQ88 (CDK11A) | Uniprot |
| K741 | Sumoylation | Uniprot | |
| K741 | Ubiquitination | Uniprot | |
| T751 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | O96017 (CHEK2) | Uniprot |
| Y762 | Phosphorylation | Uniprot | |
| S763 | Phosphorylation | Uniprot | |
| T773 | Phosphorylation | Uniprot | |
| T778 | Phosphorylation | Uniprot | |
| S785 | Phosphorylation | Uniprot | |
| S792 | Phosphorylation | Uniprot | |
| K794 | Methylation | Uniprot | |
| K794 | Sumoylation | Uniprot | |
| K794 | Ubiquitination | Uniprot |
研究背景
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
Cytoplasm. Nucleus.
Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
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