| 产品: | DOK6 抗体 |
| 货号: | DF3327 |
| 描述: | Rabbit polyclonal antibody to DOK6 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 43 KD; 38kD(Calculated). |
| 蛋白号: | Q6PKX4 |
| RRID: | AB_2835694 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3327, RRID:AB_2835694.
展开/折叠
Docking protein 5; Docking protein 5 like; Docking protein 6; DOK 6; DOK5; DOK5L; DOK6; Downstream of tyrosine kinase 6; HsT3226; MGC20785; Protein dok 5;
抗原和靶标
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
- Q6PKX4 DOK6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASNFNDIVKQGYVKIRSRKLGIFRRCWLVFKKASSKGPRRLEKFPDEKAAYFRNFHKVTELHNIKNITRLPRETKKHAVAIIFHDETSKTFACESELEAEEWCKHLCMECLGTRLNDISLGEPDLLAAGVQREQNERFNVYLMPTPNLDIYGECTMQITHENIYLWDIHNAKVKLVMWPLSSLRRYGRDSTWFTFESGRMCDTGEGLFTFQTREGEMIYQKVHSATLAIAEQHERLMLEMEQKARLQTSLTEPMTLSKSISLPRSAYWHHITRQNSVGEIYSLQGHGFGSSKMSRAQTFPSYAPEQSEEAQQPLSRSSSYGFSYSSSLIQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6PKX4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K58 | Methylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot |
研究背景
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
Interacts via its PTB domain with phosphorylated RET.
PTB domain mediates receptor interaction.
Belongs to the DOK family. Type B subfamily.
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