产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4302, RRID:AB_2836653.
展开/折叠
DKFZp686K05193; EDSS1; Ig superfamily receptor LNIR; Nectin 4; Nectin-4; poliovirus receptor-related 4; Processed poliovirus receptor-related protein 4; PRR4; pvrl4; PVRL4_HUMAN;
抗原和靶标
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
- Q96NY8 NECT4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRAEGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQAMNHFVQENGTLRAKPTGNGIYINGRGHLV
翻译修饰 - Q96NY8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S58 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| T393 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| S426 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| Y445 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| S462 | Phosphorylation | Uniprot | |
| T491 | Phosphorylation | Uniprot | |
| Y502 | Phosphorylation | Uniprot |
研究背景
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.
(Microbial infection) Acts as a receptor for measles virus.
The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Cell membrane>Single-pass type I membrane protein. Cell junction>Adherens junction.
Note: Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).
Secreted.
Note: The secreted form is found in breast tumor patients (PubMed:15784625).
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN.
(Microbial infection) Interacts with measles virus Hemagglutinin protein.
Belongs to the nectin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
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