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| 产品: | TIE1 抗体 |
| 货号: | DF4582 |
| 描述: | Rabbit polyclonal antibody to TIE1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 130 KD; 125kD(Calculated). |
| 蛋白号: | P35590 |
| RRID: | AB_2836946 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4582, RRID:AB_2836946.
展开/折叠
JKT 14; JTK14; TIE; Tie1; TIE1_HUMAN; Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine protein kinase receptor Tie 1; Tyrosine-protein kinase receptor Tie-1;
抗原和靶标
- P35590 TIE1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P35590 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T393 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| T539 | Phosphorylation | Uniprot | |
| T540 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| T604 | Phosphorylation | Uniprot | |
| T608 | Phosphorylation | Uniprot | |
| T663 | Phosphorylation | Uniprot | |
| Y912 | Phosphorylation | Uniprot | |
| Y1007 | Phosphorylation | Uniprot | |
| T1011 | Phosphorylation | Uniprot | |
| Y1027 | Phosphorylation | Uniprot | |
| Y1030 | Phosphorylation | Uniprot | |
| T1031 | Phosphorylation | Uniprot | |
| T1032 | Phosphorylation | Uniprot | |
| Y1083 | Phosphorylation | Uniprot |
研究背景
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
Cell membrane>Single-pass type I membrane protein.
Specifically expressed in developing vascular endothelial cells.
Heterodimer with TEK/TIE2.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
文献引用
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