DLGAP5 Antibody - #DF6920

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产品: DLGAP5 抗体
货号: DF6920
描述: Rabbit polyclonal antibody to DLGAP5
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 95kDa; 95kD(Calculated).
蛋白号: Q15398
RRID: AB_2838879

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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相关下载
MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(92%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(83%)
克隆:
Polyclonal
特异性:
DLGAP5 Antibody detects endogenous levels of total DLGAP5.
RRID:
AB_2838879
引用格式: Affinity Biosciences Cat# DF6920, RRID:AB_2838879.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DAP-5; DAP5; Discs large homolog 7; Disks large associated protein 5; Disks large associated protein DLG7; Disks large-associated protein 5; Disks large-associated protein DLG7; DLG 1; DLG 7; DLG1; DLG7; DLGAP5; DLGP5_HUMAN; Drosophila discs large 1 tumor suppressor like; Hepatoma up regulated protein; Hepatoma up-regulated protein; Hepatoma upregulated protein; HURP; KIAA0008;

抗原和靶标

免疫原:
Uniprot:

Q15398(DLGP5_HUMAN) >>Visit HPA database.

基因/基因ID:
DLGAP5(9787)
表达:
Q15398 DLGP5_HUMAN:

Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.

描述:
DLG7 is a potential cell cycle regulator that may play a role in carcinogenesis of cancer cells and mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. The protein is also a key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
序列:
MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNEGRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILEEGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSPLQPGEF

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Horse
92
Chicken
83
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q15398 作为底物

Site PTM Type Enzyme
S8 Phosphorylation
S15 Phosphorylation
S28 Phosphorylation
S30 Phosphorylation
S67 Phosphorylation
T84 Phosphorylation
K158 Methylation
T182 Phosphorylation
S188 Phosphorylation
K192 Acetylation
K193 Sumoylation
T201 Phosphorylation
S202 Phosphorylation
R204 Methylation
T219 Phosphorylation
S221 Phosphorylation
T224 Phosphorylation
S306 Phosphorylation
K310 Ubiquitination
T326 Phosphorylation
T329 Phosphorylation P28482 (MAPK1) , P06493 (CDK1)
S332 Phosphorylation
T338 Phosphorylation
S340 Phosphorylation
T342 Phosphorylation P24941 (CDK2)
T344 Phosphorylation P24941 (CDK2)
K347 Sumoylation
K347 Ubiquitination
T348 Phosphorylation
S353 Phosphorylation
T356 Phosphorylation
K357 Ubiquitination
K363 Ubiquitination
S368 Phosphorylation
K370 Ubiquitination
S376 Phosphorylation
K397 Ubiquitination
T401 Phosphorylation
T402 Phosphorylation
K403 Ubiquitination
K411 Ubiquitination
S415 Phosphorylation
T441 Phosphorylation
K443 Ubiquitination
K454 Ubiquitination
K464 Ubiquitination
T469 Phosphorylation
K483 Ubiquitination
K495 Ubiquitination
K529 Ubiquitination
K547 Ubiquitination
K553 Ubiquitination
K561 Ubiquitination
K580 Ubiquitination
S618 Phosphorylation P06493 (CDK1)
S624 Phosphorylation
S627 Phosphorylation O14965 (AURKA)
S629 Phosphorylation
S630 Phosphorylation
S634 Phosphorylation
T639 Phosphorylation P06493 (CDK1)
S642 Phosphorylation
K645 Ubiquitination
T661 Phosphorylation
S662 Phosphorylation
T671 Phosphorylation
S687 Phosphorylation
S689 Phosphorylation
S690 Phosphorylation
K711 Ubiquitination
K715 Ubiquitination
S720 Phosphorylation
S721 Phosphorylation
S725 Phosphorylation O14965 (AURKA)
S757 Phosphorylation O14965 (AURKA)
T759 Phosphorylation
S767 Phosphorylation
S774 Phosphorylation
S777 Phosphorylation
T784 Phosphorylation
K785 Ubiquitination
S787 Phosphorylation
S789 Phosphorylation
S796 Phosphorylation
T798 Phosphorylation
T799 Phosphorylation
S806 Phosphorylation
S812 Phosphorylation
T816 Phosphorylation
S830 Phosphorylation O14965 (AURKA)
T837 Phosphorylation
S839 Phosphorylation P06493 (CDK1)

研究背景

功能:

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

翻译修饰:

Ubiquitinated, leading to its degradation.

Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.

细胞定位:

Nucleus. Cytoplasm. Cytoplasm>Cytoskeleton>Spindle.
Note: Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.

亚基结构:

Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.

蛋白家族:

Belongs to the SAPAP family.

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