| 产品: | RASSF7 抗体 |
| 货号: | DF2230 |
| 描述: | Rabbit polyclonal antibody to RASSF7 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Horse |
| 分子量: | 40 kDa; 40kD(Calculated). |
| 蛋白号: | Q02833 |
| RRID: | AB_2839461 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2230, RRID:AB_2839461.
展开/折叠
C11orf13; Chromosome 11 open reading frame 13; HRAS1; HRAS1 related cluster 1; HRAS1 related cluster protein 1; HRAS1-related cluster protein 1; HRC1; MGC126069; MGC126070; Ras association (RalGDS/AF 6) domain family (N terminal) member 7; Ras association (RalGDS/AF 6) domain family 7; Ras association domain containing protein 7; Ras association domain-containing protein 7; RASF7_HUMAN; RASSF 7; RASSF7;
抗原和靶标
- Q02833 RASF7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q02833 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S97 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| T238 | Phosphorylation | Uniprot |
研究背景
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Note: Colocalizes with gamma-tubulin.
Interacts with MAP2K7 and GTP-bound NRAS.
限制条款
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