| 产品: | MRCKG 抗体 |
| 货号: | DF2413 |
| 描述: | Rabbit polyclonal antibody to MRCKG |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Sheep |
| 分子量: | 172kDa; 172kD(Calculated). |
| 蛋白号: | Q6DT37 |
| RRID: | AB_2839619 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2413, RRID:AB_2839619.
展开/折叠
CDC42 binding protein kinase gamma; DMPK like gamma; DMPK2; MRCK gamma; Myotonic dystrophy kinase related CDC42 binding kinase gamma; Myotonic dystrophy protein kinase like alpha; Serine/threonine protein kinase MRCK gamma; CDC42 BPG;CDC42BPG
抗原和靶标
- Q6DT37 MRCKG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6DT37 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| S646 | Phosphorylation | Uniprot | |
| K663 | Ubiquitination | Uniprot | |
| S740 | Phosphorylation | Uniprot | |
| S747 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| K875 | Ubiquitination | Uniprot | |
| S888 | Phosphorylation | Uniprot | |
| S1121 | Phosphorylation | Uniprot | |
| K1172 | Ubiquitination | Uniprot | |
| K1200 | Methylation | Uniprot | |
| K1385 | Ubiquitination | Uniprot | |
| S1462 | Phosphorylation | Uniprot | |
| R1473 | Methylation | Uniprot | |
| S1482 | Phosphorylation | Uniprot | |
| S1484 | Phosphorylation | Uniprot | |
| S1492 | Phosphorylation | Uniprot | |
| S1495 | Phosphorylation | Uniprot | |
| S1514 | Phosphorylation | Uniprot | |
| S1515 | Phosphorylation | Uniprot | |
| S1519 | Phosphorylation | Uniprot | |
| S1524 | Phosphorylation | Uniprot | |
| S1540 | Phosphorylation | Uniprot | |
| S1544 | Phosphorylation | Uniprot | |
| S1550 | Phosphorylation | Uniprot |
研究背景
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
Cytoplasm.
Note: Concentrates at the leading edge of cells.
Expressed in heart and skeletal muscle.
Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity).
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
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