CALCRL Antibody - #DF10203

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产品: CALCRL 抗体
货号: DF10203
描述: Rabbit polyclonal antibody to CALCRL
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 53 kDa; 53kD(Calculated).
蛋白号: Q16602
RRID: AB_2840782

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(91%), Bovine(91%), Horse(91%), Sheep(91%), Rabbit(100%), Dog(100%), Chicken(91%), Xenopus(86%)
克隆:
Polyclonal
特异性:
CALCRL Antibody detects endogenous levels of total CALCRL.
RRID:
AB_2840782
引用格式: Affinity Biosciences Cat# DF10203, RRID:AB_2840782.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Calcitonin gene related peptide type 1 receptor; Calcitonin receptor like; Calcitonin receptor like receptor; CALCRL; CGRP type 1 receptor; CGRPR; CRLR;

抗原和靶标

免疫原:
Uniprot:

Q16602(CALRL_HUMAN) >>Visit HPA database.

基因/基因ID:
CALCRL(10203)
表达:
Q16602 CALRL_HUMAN:

Predominantly expressed in the lung and heart.

序列:
MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Rabbit
100
Dog
100
Pig
91
Horse
91
Bovine
91
Sheep
91
Chicken
91
Xenopus
86
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q16602 作为底物

Site PTM Type Enzyme
S285 Phosphorylation
K403 Ubiquitination
S409 Phosphorylation
S445 Phosphorylation
Y460 Phosphorylation

研究背景

功能:

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

细胞定位:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Predominantly expressed in the lung and heart.

亚基结构:

Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.

蛋白家族:

Belongs to the G-protein coupled receptor 2 family.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

文献引用

1). Intermedin in Paraventricular Nucleus Attenuates Ang II-Induced Sympathoexcitation through the Inhibition of NADPH Oxidase-Dependent ROS Generation in Obese Rats with Hypertension. International Journal of Molecular Sciences (PubMed: 31466304) [IF=5.6]

Application: WB    Species: rat    Sample: paraventricular nucleus

Figure 1. |Plasma norepinephrine (NE) level (A. n = 6 or 7), systolic blood pressure (B. n = 6–7); and relative values of intermedin (IMD), calcitonin receptor–like receptor (CRLR) and receptor activity–modifying protein (RAMP) 1, RAMP2, and RAMP3 protein expression in the paraventricular nucleus (PVN) in control and obesity-related hypertensive (OH) rats (C–H. n = 3–4). Values are mean± SEM. * p < 0.05 versus control.
2). Exogenous CGRP Regulates Apoptosis and Autophagy to Alleviate Traumatic Brain Injury Through Akt/mTOR Signalling Pathway. NEUROCHEMICAL RESEARCH (PubMed: 33063244) [IF=4.4]

Application: WB    Species: mouse    Sample: brain cortical

Fig. 1 CGRP alleviated the brain lesion induced by TBI. a Relative protein expression of CGRP in the brain cortical tissues with or without CGRP administration after TBI over time was detected by western blot (loading volume of CGRP: 15 μg).
3). Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. ACTA DIABETOLOGICA (PubMed: 34978596) [IF=3.8]
4). Correlation of vascular change with TRPV1, TRPV4, and TRPA1 in a rat model of inferior gluteal artery perforator flap. WOUND REPAIR AND REGENERATION (PubMed: 35384152) [IF=2.9]

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