CD11c Antibody - #DF7585

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产品: CD11c 抗体
货号: DF7585
描述: Rabbit polyclonal antibody to CD11c
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Rabbit, Dog
分子量: 130~150kDa; 128kD(Calculated).
蛋白号: P20702
RRID: AB_2841076

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 50ul RMB¥ 1500 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(91%), Bovine(91%), Horse(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
CD11c Antibody detects endogenous levels of total CD11c.
RRID:
AB_2841076
引用格式: Affinity Biosciences Cat# DF7585, RRID:AB_2841076.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

95 alpha chain; 95; CD 11c; CD11 antigen like family member C; CD11 antigen-like family member C; CD11c; CD11c antigen; Complement component 3 receptor 4 subunit; CR4; Integrin alpha X; Integrin alpha X chain; Integrin alpha-X; Integrin aX; Integrin subunit alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit; ITAX_HUMAN; ITGAX; LEU M5 alpha subunit; Leu M5; Leukocyte adhesion glycoprotein p150 95 alpha chain; Leukocyte adhesion glycoprotein p150; Leukocyte adhesion receptor p150 95; Leukocyte adhesion receptor p150; Leukocyte surface antigen p150 95 alpha subunit; Leukocyte surface antigen p150 alpha subunit; Myeloid membrane antigen alpha subunit; p150 95 integrin alpha chain; p150; p150/95; SLEB6;

抗原和靶标

免疫原:
Uniprot:

P20702(ITAX_HUMAN) >>Visit HPA database.

基因/基因ID:
ITGAX(3687)
表达:
P20702 ITAX_HUMAN:

Predominantly expressed in monocytes and granulocytes.

序列:
MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAGFGDSVVQYANSWVVVGAPQKITAANQTGGLYQCGYSTGACEPIGLQVPPEAVNMSLGLSLASTTSPSQLLACGPTVHHECGRNMYLTGLCFLLGPTQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVISQFQRPSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQGFTYTATAIQNVVHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVGLAFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEGTETTSSSSFELEMAQEGFSAVFTPDGPVLGAVGSFTWSGGAFLYPPNMSPTFINMSQENVDMRDSYLGYSTELALWKGVQSLVLGAPRYQHTGKAVIFTQVSRQWRMKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGWRRWWCDAVLYGEQGHPWGRFGAALTVLGDVNGDKLTDVVIGAPGEEENRGAVYLFHGVLGPSISPSHSQRIAGSQLSSRLQYFGQALSGGQDLTQDGLVDLAVGARGQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQSNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGLKAHCENFNLLLPSCVEDSVTPITLRLNFTLVGKPLLAFRNLRPMLAADAQRYFTASLPFEKNCGADHICQDNLGISFSFPGLKSLLVGSNLELNAEVMVWNDGEDSYGTTITFSHPAGLSYRYVAEGQKQGQLRSLHLTCDSAPVGSQGTWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLLLTANVSSENNTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKESHVAMHRYQVNNLGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQNPSLRCSSEKIAPPASDFLAHIQKNPVLDCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSVYSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFKRQYKEMMEEANGQIAPENGTQTPSPPSEK

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Dog
100
Rabbit
100
Pig
91
Bovine
91
Sheep
67
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P20702 作为底物

Site PTM Type Enzyme
N61 N-Glycosylation
N392 N-Glycosylation
S668 Phosphorylation
S673 Phosphorylation
S674 Phosphorylation
N697 N-Glycosylation
N735 N-Glycosylation
N899 N-Glycosylation
S1158 Phosphorylation

研究背景

功能:

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

细胞定位:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Predominantly expressed in monocytes and granulocytes.

亚基结构:

Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

蛋白家族:

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Belongs to the integrin alpha chain family.

研究领域

· Cellular Processes > Cell motility > Regulation of actin cytoskeleton.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Anti-inflammatory effect of piperine ameliorates insulin resistance in monosodium glutamate–treated obese mice. METABOLISM-CLINICAL AND EXPERIMENTAL (PubMed: 19800637) [IF=9.8]

Application: WB    Species: Mouse    Sample: RAW264.7 cells

Figure 9. Effects of piperine on LPS-induced M1-like polarization in RAW264.7 cells. RAW264.7 cells were pretreated with piperine at 20-80 μM for 12 h and then stimulated by LPS (1 μg/ml) for 24 h. (a-c) The mRNA levels of CD11c, IL-1β and TNF-α were analyzed by qPCR. (d) The IL-1β level in cell supernatant was measured by ELISA. (e-f) The protein levels of TLR-4, CD11c and IL-1β were tested by Western Blotting. Data are expressed as mean±SD, n=3. ####p

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