Thymidylate Synthase Antibody - #DF8096

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产品: Thymidylate Synthase 抗体
货号: DF8096
描述: Rabbit polyclonal antibody to Thymidylate Synthase
应用: WB
反应: Human, Monkey
预测: Pig, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
分子量: 36 kDa; 36kD(Calculated).
蛋白号: P04818
RRID: AB_2841443

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Monkey
预测:
Pig(100%), Bovine(100%), Horse(86%), Sheep(100%), Rabbit(100%), Chicken(88%), Xenopus(88%)
克隆:
Polyclonal
特异性:
Thymidylate Synthase Antibody detects endogenous levels of total Thymidylate Synthase.
RRID:
AB_2841443
引用格式: Affinity Biosciences Cat# DF8096, RRID:AB_2841443.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

d TMP synthase; EC 2.1.1.45; HsT422; MGC88736; OTTHUMP00000162195; Thymidylate synthase; Thymidylate synthetase; TMS; TS; TSase; Tyms; TYMS protein; Tyms thymidylate synthetase; TYSY_HUMAN;

抗原和靶标

免疫原:
Uniprot:

P04818(TYSY_HUMAN) >>Visit HPA database.

基因/基因ID:
TYMS(7298)
序列:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Rabbit
100
Xenopus
88
Chicken
88
Horse
86
Zebrafish
75
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P04818 作为底物

Site PTM Type Enzyme
S6 Phosphorylation
T53 Phosphorylation
K77 Ubiquitination
K93 Ubiquitination
K99 Ubiquitination
K104 Ubiquitination
K107 Ubiquitination
S114 Phosphorylation
S120 Phosphorylation
S124 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2)
Y135 Phosphorylation
Y146 Phosphorylation
S151 Phosphorylation
Y153 Phosphorylation
S154 Phosphorylation
T167 Phosphorylation
K169 Ubiquitination
K278 Ubiquitination
K284 Ubiquitination
K287 Sumoylation
K287 Ubiquitination
K292 Sumoylation
K292 Ubiquitination
K308 Sumoylation
K308 Ubiquitination

研究背景

功能:

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

细胞定位:

Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer.

蛋白家族:

Belongs to the thymidylate synthase family.

研究领域

· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.

· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.

· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.

· Metabolism > Global and overview maps > Metabolic pathways.

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