产品: IL22 抗体
货号: DF8343
描述: Rabbit polyclonal antibody to IL22
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Dog
分子量: 20 kDa; 20kD(Calculated).
蛋白号: Q9GZX6
RRID: AB_2841610

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(88%), Dog(100%)
克隆:
Polyclonal
特异性:
IL22 Antibody detects endogenous levels of total IL22.
RRID:
AB_2841610
引用格式: Affinity Biosciences Cat# DF8343, RRID:AB_2841610.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Cytokine Zcyto18; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; IL-10-related T-cell-derived-inducible factor; IL-22; IL-TIF; IL21; Il22; IL22_HUMAN; ILD110; ILTIF; Interleukin 10 related T cell derived inducible factor; interleukin 21; Interleukin 22; Interleukin-22; MGC79382; MGC79384; TIFa; TIFIL 23; TIFIL23; UNQ3099/PRO10096; zcyto18;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
序列:
MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNACI

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Dog
100
Pig
88
Horse
79
Rabbit
74
Chicken
67
Bovine
63
Sheep
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9GZX6 作为底物

Site PTM Type Enzyme
N54 N-Glycosylation
N97 N-Glycosylation
S126 Phosphorylation

研究背景

功能:

Cytokine that contributes to the inflammatory response in vivo.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the IL-10 family.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

文献引用

1). Th22 cells induce Müller cell activation via the Act1/TRAF6 pathway in diabetic retinopathy. CELL AND TISSUE RESEARCH (PubMed: 36201050) [IF=3.6]

2). Chlamydia muridarum Alleviates Colitis via the IL-22/Occludin Signal Pathway. Biomed Research International (PubMed: 33381598)

Application: WB    Species: Mice    Sample: colon tissue

Figure 3 Chlamydia muridarum upregulates IL-22 and occludin expression in mice with dextran sodium sulfate- (DSS-) induced colitis. (a) IL-22 and occludin expression in various groups assessed using western blotting. (b) Relative protein expression of IL-22 and occludin. (n = 3 per group). ∗P < 0.05, DSS group compared with control group; #P < 0.05, CM+DSS group compared with DSS group; &P < 0.05, CM+DSS+aIL-22 group compared with CM+DSS group.

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