LSS Antibody - #DF8379
| 产品: | LSS 抗体 |
| 货号: | DF8379 |
| 描述: | Rabbit polyclonal antibody to LSS |
| 应用: | WB IHC |
| 反应: | Human, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 83 kDa; 83kD(Calculated). |
| 蛋白号: | P48449 |
| RRID: | AB_2841641 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8379, RRID:AB_2841641.
展开/折叠
2,3 epoxysqualene lanosterol cyclase; hOSC; Lanosterol synthase (2,3 oxidosqualene lanosterol cyclase); Lanosterol synthase; OSC; Oxidosqualene lanosterol cyclase;
抗原和靶标
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
- P48449 ERG7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P48449 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T2 | Acetylation | Uniprot | |
| R10 | Methylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| Y158 | Phosphorylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| S249 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| Y320 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| Y368 | Phosphorylation | Uniprot | |
| K432 | Ubiquitination | Uniprot | |
| K439 | Ubiquitination | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| K680 | Ubiquitination | Uniprot | |
| K698 | Ubiquitination | Uniprot |
研究背景
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Endoplasmic reticulum membrane>Peripheral membrane protein.
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
Monomer.
Belongs to the terpene cyclase/mutase family.
研究领域
· Metabolism > Lipid metabolism > Steroid biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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