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产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8551, RRID:AB_2841755.
展开/折叠
GC S alpha 1; GC SA3; GCS alpha 1; GCS alpha 3; GCS-alpha-1; GCS-alpha-3; GCYA3_HUMAN; Guanylate cyclase 1 soluble alpha 3; Guanylate cyclase soluble subunit alpha 1; Guanylate cyclase soluble subunit alpha 3; Guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, nitric oxide-sensitive, alpha-1 subunit; Guc1a1; GUC1A3; GUCA3; GUCSA3; Gucy1a1; Gucy1a3; MYMY6; nitric oxide-sensitive Guanylate cyclase, alpha-1 subunit; NOGC, alpha-1 subunit; Soluble guanylate cyclase large subunit;
抗原和靶标
- Q02108 GCYA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q02108 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S58 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| T73 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| Y523 | Phosphorylation | Uniprot | |
| K606 | Ubiquitination | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| K627 | Ubiquitination | Uniprot |
研究背景
Cytoplasm.
Detected in brain cortex and lung (at protein level).
The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1.
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Salivary secretion.
文献引用
Application: WB Species: human Sample: GC cells
限制条款
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