ZHX2 Antibody - #DF8899

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产品: ZHX2 抗体
货号: DF8899
描述: Rabbit polyclonal antibody to ZHX2
应用: WB IHC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 92 kDa; 92kD(Calculated).
蛋白号: Q9Y6X8
RRID: AB_2842095

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(92%), Horse(83%), Sheep(92%), Rabbit(83%), Dog(100%)
克隆:
Polyclonal
特异性:
ZHX2 Antibody detects endogenous levels of total ZHX2.
RRID:
AB_2842095
引用格式: Affinity Biosciences Cat# DF8899, RRID:AB_2842095.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AFP regulator 1; AFR1; Alpha fetoprotein regulator 1; Alpha-fetoprotein regulator 1; KIAA0854; RAF; Regulator of AFP; Transcription factor ZHX2; ZHX2; ZHX2_HUMAN; Zinc finger and homeodomain protein 2; Zinc fingers and homeoboxes 2; Zinc fingers and homeoboxes protein 2;

抗原和靶标

免疫原:
Uniprot:

Q9Y6X8(ZHX2_HUMAN) >>Visit HPA database.

基因/基因ID:
ZHX2(22882)
表达:
Q9Y6X8 ZHX2_HUMAN:

Ubiquitously expressed. Expressed in podocytes.

序列:
MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Dog
100
Bovine
92
Sheep
92
Horse
83
Rabbit
83
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9Y6X8 作为底物

Site PTM Type Enzyme
S7 Phosphorylation
T8 Phosphorylation
T9 Phosphorylation
T37 Phosphorylation
T207 Phosphorylation
T215 Phosphorylation
T220 Phosphorylation
T222 Phosphorylation
Y267 Phosphorylation
S269 Phosphorylation
T344 Phosphorylation
T355 Phosphorylation
T401 Phosphorylation
T411 Phosphorylation
T439 Phosphorylation
S442 Phosphorylation
K455 Ubiquitination
Y470 Phosphorylation
T566 Phosphorylation
S569 Phosphorylation
S586 Phosphorylation
S625 Phosphorylation
S628 Phosphorylation
T654 Phosphorylation
Y658 Phosphorylation
Y705 Phosphorylation
T713 Phosphorylation
S719 Phosphorylation
S769 Phosphorylation
S775 Phosphorylation
S776 Phosphorylation

研究背景

功能:

Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).

细胞定位:

Nucleus.
Note: Colocalizes with EFNB1 intracellular domain in the nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitously expressed. Expressed in podocytes.

亚基结构:

Homodimer (via homeobox domain). Heterodimer with ZHX1 (via homeobox domain 1). Heterodimer with ZHX3 (via homeobox domain 1). Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts (via homeobox domain) with NFYA (via N-terminus). Interacts with EFNB1 intracellular domain peptide; the interaction enhances ZHX2 transcriptional repression activity (By similarity).

蛋白家族:

Belongs to the ZHX family.

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