(1)
(5)
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9260, RRID:AB_2842456.
展开/折叠
inwardly rectifying subfamily J member 10; ATP dependent inwardly rectifying potassium channel Kir4.1; ATP sensitive inward rectifier potassium channel 10; ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; BIRK10; Glial ATP dependent inwardly rectifying potassium channel KIR4.1; Inward rectifier K(+) channel Kir1.2; Inward rectifier K+ channel KIR1.2; Inwardly rectifying potassium channel Kir1.2; KCJ10_HUMAN; KCNJ 10; Kcnj10; KCNJ13 PEN; KIR1.2; KIR4.1; Potassium channel; Potassium channel inwardly rectifying subfamily J member 10; Potassium inwardly rectifying channel subfamily J member 10; SESAME;
抗原和靶标
- P78508 KCJ10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P78508 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y8 | Phosphorylation | Uniprot | |
| Y9 | Phosphorylation | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S377 | Phosphorylation | Uniprot |
研究背景
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
Membrane>Multi-pass membrane protein. Basolateral cell membrane.
Note: In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
Expressed in kidney (at protein level).
Heterodimer with Kir5.1/KCNJ16; this interaction is required for KCNJ16 localization to the basolateral membrane in kidney cells. Interacts with MAGI1, alone and possibly as a heterodimer with KCNJ16; this interaction may facilitate KCNJ10/KCNJ16 potassium channel expression at the basolateral membrane in kidney cells. Interacts with PATJ (By similarity).
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
研究领域
· Organismal Systems > Digestive system > Gastric acid secretion.
文献引用
Application: WB Species: Rat Sample: kidney tissues
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