| 产品: | ACSL5 抗体 |
| 货号: | DF9607 |
| 描述: | Rabbit polyclonal antibody to ACSL5 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Horse, Rabbit |
| 分子量: | 76kDa; 76kD(Calculated). |
| 蛋白号: | Q9ULC5 |
| RRID: | AB_2842803 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9607, RRID:AB_2842803.
展开/折叠
ACS2; ACS5; Acyl CoA synthetase 5; Acyl CoA synthetase long chain family member 5; EC 6.2.1.3; FACL5; FACL5 for fatty acid coenzyme A ligase 5; Fatty acid CoA ligase, long chain 5; Fatty acid coenzyme A ligase 5; Fatty acid Coenzyme A ligase long chain 5; LACS 5; Long chain acyl CoA synthetase 5; Long chain fatty acid CoA ligase 5; Long chain fatty acid coenzyme A ligase 5;
抗原和靶标
- Q9ULC5 ACSL5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLFIFNFLFSPLPTPALICILTFGAAIFLWLITRPQPVLPLLDLNNQSVGIEGGARKGVSQKNNDLTSCCFSDAKTMYEVFQRGLAVSDNGPCLGYRKPNQPYRWLSYKQVSDRAEYLGSCLLHKGYKSSPDQFVGIFAQNRPEWIISELACYTYSMVAVPLYDTLGPEAIVHIVNKADIAMVICDTPQKALVLIGNVEKGFTPSLKVIILMDPFDDDLKQRGEKSGIEILSLYDAENLGKEHFRKPVPPSPEDLSVICFTSGTTGDPKGAMITHQNIVSNAAAFLKCVEHAYEPTPDDVAISYLPLAHMFERIVQAVVYSCGARVGFFQGDIRLLADDMKTLKPTLFPAVPRLLNRIYDKVQNEAKTPLKKFLLKLAVSSKFKELQKGIIRHDSFWDKLIFAKIQDSLGGRVRVIVTGAAPMSTSVMTFFRAAMGCQVYEAYGQTECTGGCTFTLPGDWTSGHVGVPLACNYVKLEDVADMNYFTVNNEGEVCIKGTNVFKGYLKDPEKTQEALDSDGWLHTGDIGRWLPNGTLKIIDRKKNIFKLAQGEYIAPEKIENIYNRSQPVLQIFVHGESLRSSLVGVVVPDTDVLPSFAAKLGVKGSFEELCQNQVVREAILEDLQKIGKESGLKTFEQVKAIFLHPEPFSIENGLLTPTLKAKRGELSKYFRTQIDSLYEHIQD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9ULC5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y96 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| Y234 | Phosphorylation | Uniprot | |
| K241 | Methylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S395 | Phosphorylation | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| Y552 | Phosphorylation | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| S581 | Phosphorylation | Uniprot | |
| S595 | Phosphorylation | Uniprot | |
| K599 | Ubiquitination | Uniprot | |
| K603 | Ubiquitination | Uniprot | |
| T634 | Phosphorylation | Uniprot | |
| T656 | Phosphorylation | Uniprot | |
| Y678 | Phosphorylation | Uniprot |
研究背景
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein. Cell membrane.
Belongs to the ATP-dependent AMP-binding enzyme family.
研究领域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
限制条款
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