WBSCR11 Antibody - #AF9231

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产品: WBSCR11 抗体
货号: AF9231
描述: Rabbit polyclonal antibody to WBSCR11
应用: WB IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 106kDa; 106kD(Calculated).
蛋白号: Q9UHL9
RRID: AB_2843421

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产品描述

来源:
Rabbit
应用:
WB 1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(90%), Bovine(90%), Horse(90%), Sheep(90%), Rabbit(100%), Dog(90%)
克隆:
Polyclonal
特异性:
WBSCR11 Antibody detects endogenous levels of total WBSCR11.
RRID:
AB_2843421
引用格式: Affinity Biosciences Cat# AF9231, RRID:AB_2843421.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CREAM1; General transcription factor II I repeat domain containing protein 1; General transcription factor II-I repeat domain-containing protein 1; General transcription factor III; GT2D1_HUMAN; GTF2I repeat domain containing protein 1; GTF2I repeat domain-containing protein 1; GTF2IRD1; GTF3; Muscle TFII I repeat domain-containing protein 1; Muscle TFII-I repeat domain-containing protein 1; MUSTRD1; MusTRD1/BEN; RBAP2; Slow muscle fiber enhancer binding protein; Slow-muscle-fiber enhancer-binding protein; USE B1 binding protein; USE B1-binding protein; WBSCR11; WBSCR12; Williams Beuren syndrome chromosome region 11 protein; Williams-Beuren syndrome chromosomal region 11 protein; Williams-Beuren syndrome chromosomal region 12 protein;

抗原和靶标

免疫原:
Uniprot:

Q9UHL9(GT2D1_HUMAN) >>Visit HPA database.

基因/基因ID:
GTF2IRD1(9569)
表达:
Q9UHL9 GT2D1_HUMAN:

Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.

序列:
MALLGKRCDVPTNGCGPDRWNSAFTRKDEIITSLVSALDSMCSALSKLNAEVACVAVHDESAFVVGTEKGRMFLNARKELQSDFLRFCRGPPWKDPEAEHPKKVQRGEGGGRSLPRSSLEHGSDVYLLRKMVEEVFDVLYSEALGRASVVPLPYERLLREPGLLAVQGLPEGLAFRRPAEYDPKALMAILEHSHRIRFKLKRPLEDGGRDSKALVELNGVSLIPKGSRDCGLHGQAPKVPPQDLPPTATSSSMASFLYSTALPNHAIRELKQEAPSCPLAPSDLGLSRPMPEPKATGAQDFSDCCGQKPTGPGGPLIQNVHASKRILFSIVHDKSEKWDAFIKETEDINTLRECVQILFNSRYAEALGLDHMVPVPYRKIACDPEAVEIVGIPDKIPFKRPCTYGVPKLKRILEERHSIHFIIKRMFDERIFTGNKFTKDTTKLEPASPPEDTSAEVSRATVLDLAGNARSDKGSMSEDCGPGTSGELGGLRPIKIEPEDLDIIQVTVPDPSPTSEEMTDSMPGHLPSEDSGYGMEMLTDKGLSEDARPEERPVEDSHGDVIRPLRKQVELLFNTRYAKAIGISEPVKVPYSKFLMHPEELFVVGLPEGISLRRPNCFGIAKLRKILEASNSIQFVIKRPELLTEGVKEPIMDSQGTASSLGFSPPALPPERDSGDPLVDESLKRQGFQENYDARLSRIDIANTLREQVQDLFNKKYGEALGIKYPVQVPYKRIKSNPGSVIIEGLPPGIPFRKPCTFGSQNLERILAVADKIKFTVTRPFQGLIPKPDEDDANRLGEKVILREQVKELFNEKYGEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEGNSVSSSSSSSSSSSSNPDSVASANQISLVQWPMYMVDYAGLNVQLPGPLNY

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Rabbit
100
Pig
90
Horse
90
Bovine
90
Sheep
90
Dog
90
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UHL9 作为底物

Site PTM Type Enzyme
K94 Ubiquitination
S113 Phosphorylation
K130 Ubiquitination
S193 Phosphorylation
K201 Ubiquitination
K212 Sumoylation
K225 Sumoylation
K271 Sumoylation
K271 Ubiquitination
K308 Sumoylation
K308 Ubiquitination
S329 Phosphorylation
K337 Sumoylation
K337 Ubiquitination
K379 Sumoylation
K379 Ubiquitination
K395 Ubiquitination
T403 Phosphorylation
Y404 Phosphorylation
S418 Phosphorylation
K436 Sumoylation
K436 Ubiquitination
K443 Sumoylation
K443 Ubiquitination
S448 Phosphorylation
T461 Phosphorylation
S471 Phosphorylation
S475 Phosphorylation
S477 Phosphorylation
K495 Sumoylation
K567 Sumoylation
Y577 Phosphorylation
K579 Sumoylation
K579 Ubiquitination
S584 Phosphorylation
K638 Sumoylation
S654 Phosphorylation
K684 Sumoylation
K684 Ubiquitination
T704 Phosphorylation
K715 Ubiquitination
K716 Ubiquitination
Y717 Phosphorylation
K724 Sumoylation
K724 Ubiquitination
K754 Ubiquitination
K787 Sumoylation
K799 Ubiquitination
K807 Ubiquitination
Y814 Phosphorylation
Y828 Phosphorylation
K829 Sumoylation
K829 Ubiquitination
S834 Phosphorylation
S906 Phosphorylation
S914 Phosphorylation
S915 Phosphorylation
S916 Phosphorylation
S917 Phosphorylation

研究背景

功能:

May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.

亚基结构:

Interacts with the retinoblastoma protein (RB1) via its C-terminus.

蛋白家族:

The N-terminal half may have an activating activity.

Belongs to the TFII-I family.

研究领域

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Genetic Information Processing > Transcription > Basal transcription factors.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

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