产品: ketohexokinase 抗体
货号: AF7029
描述: Rabbit polyclonal antibody to ketohexokinase
应用: WB
反应: Human, Mouse
预测: Bovine, Horse, Sheep
分子量: 33 KD; 33kD(Calculated).
蛋白号: P50053
RRID: AB_2843469

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Bovine(88%), Horse(100%), Sheep(88%)
克隆:
Polyclonal
特异性:
ketohexokinase Antibody detects endogenous levels of total ketohexokinase.
RRID:
AB_2843469
引用格式: Affinity Biosciences Cat# AF7029, RRID:AB_2843469.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EC 2.7.1.3; Fructokinase; Hepatic fructokinase; Ketohexokinase; Ketohexokinase isoform a; KHK; KHK_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human ketohexokinase, corresponding to a region within N-terminal amino acids.

Uniprot:
基因/基因ID:
表达:
P50053 KHK_HUMAN:

Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.

描述:
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
序列:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
88
Sheep
88
Pig
63
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P50053 作为底物

Site PTM Type Enzyme
S90 Phosphorylation
S116 Phosphorylation
K134 Ubiquitination
K148 Ubiquitination
K197 Ubiquitination

研究背景

功能:

Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.

组织特异性:

Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.

亚基结构:

Homodimer.

蛋白家族:

Belongs to the carbohydrate kinase PfkB family.

研究领域

· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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