PLD2 Antibody - #AF7603

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产品: PLD2 抗体
货号: AF7603
描述: Rabbit polyclonal antibody to PLD2
应用: WB
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Dog, Xenopus
分子量: 106kDa; 106kD(Calculated).
蛋白号: O14939
RRID: AB_2843967

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Xenopus(89%)
克隆:
Polyclonal
特异性:
PLD2 Antibody detects endogenous levels of total PLD2.
RRID:
AB_2843967
引用格式: Affinity Biosciences Cat# AF7603, RRID:AB_2843967.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Choline phosphatase 2; EC 3.1.4.4; hPLD 2; hPLD2; mPLD2; Phosphatidylcholine hydrolyzing phospholipase D2; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PhospholipaseD2; PLD 2; PLD1C; Pld2; PLD2_HUMAN; Pldc; rPLD2;

抗原和靶标

免疫原:
Uniprot:

O14939(PLD2_HUMAN) >>Visit HPA database.

基因/基因ID:
PLD2(5338)
表达:
O14939 PLD2_HUMAN:

Ubiquitous.

序列:
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
89
Chicken
63
Pig
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - O14939 作为底物

Site PTM Type Enzyme
T29 Phosphorylation
T72 Phosphorylation
S77 Phosphorylation
S79 Phosphorylation
K80 Ubiquitination
T99 Phosphorylation
T100 Phosphorylation
K118 Ubiquitination
S134 Phosphorylation Q00535 (CDK5)
S146 Phosphorylation
T156 Phosphorylation
S161 Phosphorylation
Y169 Phosphorylation
T175 Phosphorylation
Y179 Phosphorylation P00533 (EGFR)
S213 Phosphorylation
S243 Phosphorylation P17252 (PRKCA)
T252 Phosphorylation P17252 (PRKCA)
K292 Methylation
Y296 Phosphorylation P00533 (EGFR)
K388 Methylation
K388 Ubiquitination
Y415 Phosphorylation P52333 (JAK3)
S416 Phosphorylation
T488 Phosphorylation
Y511 Phosphorylation P12931 (SRC)
T566 Phosphorylation Q05655 (PRKCD)
Y573 Phosphorylation
Y578 Phosphorylation
Y580 Phosphorylation
K656 Ubiquitination

研究背景

功能:

May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

翻译修饰:

Phosphorylated by FGR.

细胞定位:

Membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous.

亚基结构:

Interacts with EGFR (By similarity). Interacts with PIP5K1B.

蛋白家族:

Belongs to the phospholipase D family.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Choline metabolism in cancer.   (View pathway)

· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.

· Metabolism > Lipid metabolism > Ether lipid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis.   (View pathway)

· Organismal Systems > Nervous system > Glutamatergic synapse.

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