IFNGR1 Antibody - #AF7734
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| 产品: | IFNGR1 抗体 |
| 货号: | AF7734 |
| 描述: | Rabbit polyclonal antibody to IFNGR1 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 50~100kD; 54kD(Calculated). |
| 蛋白号: | P15260 |
| RRID: | AB_2844098 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7734, RRID:AB_2844098.
展开/折叠
Antiviral Protein Type II; Antiviral protein, type 2; AVP type II; AVP, type 2; CD 119; CD119; CD119 antigen; CDw119; FLJ45734; IFN gamma R alpha; IFN gamma R; IFN gamma R1; IFN-gamma receptor 1; IFN-gamma-R1; IFNG R1; IFNGR 1; IFNGR; IFNGR1; Immune interferon receptor 1; Immune interferon receptor for; INGR1_HUMAN; Interferon gamma receptor 1; Interferon gamma receptor alpha chain; Interferon gamma receptor alpha chain precursor;
抗原和靶标
- P15260 INGR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P15260 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K115 | Ubiquitination | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| T295 | Phosphorylation | Uniprot | |
| T298 | Phosphorylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| Y304 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| T309 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| S391 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| Y397 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| Y457 | Phosphorylation | P23458 (JAK1) | Uniprot |
| K459 | Ubiquitination | Uniprot | |
| Y479 | Phosphorylation | Uniprot |
研究背景
Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents.
Phosphorylated at Ser/Thr residues.
Cell membrane>Single-pass type I membrane protein.
Monomer. Heterodimer with IFNGR2, to form the IFNG receptor complex. Interacts with JAK1.
Belongs to the type II cytokine receptor family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
文献引用
Application: WB Species: Mouse Sample:
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