p50 Dynamitin Antibody - #AF0232

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产品: p50 Dynamitin 抗体
货号: AF0232
描述: Rabbit polyclonal antibody to p50 Dynamitin
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 50kDa; 44kD(Calculated).
蛋白号: Q13561
RRID: AB_2833407

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(92%), Zebrafish(82%), Bovine(83%), Horse(83%), Sheep(83%), Rabbit(100%), Dog(92%)
克隆:
Polyclonal
特异性:
p50 Dynamitin Antibody detects endogenous levels of total p50 Dynamitin.
RRID:
AB_2833407
引用格式: Affinity Biosciences Cat# AF0232, RRID:AB_2833407.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

50 kD dynein associated polypeptide; 50 kDa dynein associated polypeptide; 50 kDa dynein-associated polypeptide; DCTN-50; DCTN2; DCTN2_HUMAN; DCTN50; dynactin 2 (p50); dynactin 2; dynactin complex 50 kD subunit; Dynactin complex 50 kDa subunit; Dynactin subunit 2; DYNAMITIN; p50 dynamitin; RBP50;

抗原和靶标

免疫原:
Uniprot:

Q13561(DCTN2_HUMAN) >>Visit HPA database.

基因/基因ID:
DCTN2(10540)
描述:
dynactin 2 Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. Belongs to the dynactin subunit 2 family. Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135. Interacts with MAPRE1.
序列:
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQLEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRCDQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMIANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Rabbit
100
Pig
92
Dog
92
Horse
83
Bovine
83
Sheep
83
Zebrafish
82
Xenopus
70
Chicken
67
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q13561 作为底物

Site PTM Type Enzyme
A2 Acetylation
K5 Ubiquitination
Y6 Phosphorylation
Y54 Phosphorylation
K65 Methylation
K65 Ubiquitination
S70 Phosphorylation
R72 Methylation
Y81 Phosphorylation
S83 Phosphorylation
Y86 Phosphorylation
T98 Phosphorylation
K102 Ubiquitination
T115 Phosphorylation
K119 Ubiquitination
K125 Ubiquitination
S127 Phosphorylation
T134 Phosphorylation
K140 Ubiquitination
K146 Ubiquitination
S152 Phosphorylation
K156 Ubiquitination
K175 Ubiquitination
T198 Phosphorylation
S202 Phosphorylation
Y207 Phosphorylation
K217 Ubiquitination
K223 Ubiquitination
T232 Phosphorylation
S249 Phosphorylation
T260 Phosphorylation
S285 Phosphorylation
K289 Ubiquitination
K297 Ubiquitination
K308 Acetylation
K308 Ubiquitination
Y313 Phosphorylation
T315 Phosphorylation
S320 Phosphorylation

研究背景

功能:

Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

细胞定位:

Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By similarity). Interacts with DYNAP. Interacts with ECPAS. Interacts with MAPRE1.

蛋白家族:

Belongs to the dynactin subunit 2 family.

研究领域

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.

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