LPCAT1 Antibody - #DF12033
| 产品: | LPCAT1 抗体 |
| 货号: | DF12033 |
| 描述: | Rabbit polyclonal antibody to LPCAT1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Zebrafish, Bovine, Horse, Dog, Chicken |
| 分子量: | 59 kDa; 59kD(Calculated). |
| 蛋白号: | Q8NF37 |
| RRID: | AB_2844838 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12033, RRID:AB_2844838.
展开/折叠
1 acylglycerophosphocholine O acyltransferase; 1 alkylglycerophosphocholine O acetyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; Acetyl CoA:lyso PAF acetyltransferase; Acetyl CoA:lyso platelet activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyl CoA:lysophosphatidylcholine acyltransferase 1; Acyltransferase like 2; Acyltransferase-like 2; AGPAT10; AGPAT9; AYTL1; AYTL2; FLJ12443; FLJ41609; LPC acyltransferase 1; LPC acyltransferase; lpcat; LPCAT-1; LPCAT1; Lyso PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; LysoPC acyltransferase 1; Lysophosphatidylcholine acyltransferase 1; PCAT1_HUMAN; PFAAP3; Phosphonoformate immuno associated protein 3; Phosphonoformate immuno-associated protein 3;
抗原和靶标
- Q8NF37 PCAT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRLRGCGPRAAPASSAGASDARLLAPPGRNPFVHELRLSALQKAQVALMTLTLFPVRLLVAAAMMLLAWPLALVASLGSAEKEPEQPPALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIQYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGAPVQPVVLRYPNKLDTITWTWQGPGALEILWLTLCQFHNQVEIEFLPVYSPSEEEKRNPALYASNVRRVMAEALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPEKLEKDLDRYSERARMKGGEKIGIAEFAASLEVPVSDLLEDMFSLFDESGSGEVDLRECVVALSVVCRPARTLDTIQLAFKMYGAQEDGSVGEGDLSCILKTALGVAELTVTDLFRAIDQEEKGKITFADFHRFAEMYPAFAEEYLYPDQTHFESCAETSPAPIPNGFCADFSPENSDAGRKPVRKKLD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8NF37 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T52 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K221 | Acetylation | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| K344 | Ubiquitination | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| K470 | Ubiquitination | Uniprot |
研究背景
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size.
Endoplasmic reticulum membrane>Single-pass type II membrane protein. Golgi apparatus membrane>Single-pass type II membrane protein. Lipid droplet.
Note: May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
研究领域
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.
· Metabolism > Lipid metabolism > Ether lipid metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
限制条款
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