PYGB Antibody - #DF12308

(2)  
产品: PYGB 抗体
货号: DF12308
描述: Rabbit polyclonal antibody to PYGB
应用: WB IHC
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 97 kDa; 97kD(Calculated).
蛋白号: P11216
RRID: AB_2845113

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
PYGB Antibody detects endogenous levels of total PYGB.
RRID:
AB_2845113
引用格式: Affinity Biosciences Cat# DF12308, RRID:AB_2845113.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Brain glycogen phosphorylase; Glycogen phosphorylase B; Glycogen phosphorylase brain form; Glycogen Phosphorylase Isoenzyme BB; Glycogen phosphorylase, brain form; MGC9213; Phosphorylase glycogen brain; PYGB; PYGB_HUMAN;

抗原和靶标

免疫原:
Uniprot:

P11216(PYGB_HUMAN) >>Visit HPA database.

基因/基因ID:
PYGB(5834)
序列:
MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNIPRD

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
100
Chicken
100
Rabbit
100
Pig
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P11216 作为底物

Site PTM Type Enzyme
A2 Acetylation
K3 Acetylation
K3 Ubiquitination
T6 Phosphorylation
S8 Phosphorylation
K10 Acetylation
K10 Ubiquitination
S15 Phosphorylation Q8IWU2 (LMTK2)
S31 Phosphorylation
T39 Phosphorylation
K42 Ubiquitination
Y52 Phosphorylation
Y75 Phosphorylation
Y76 Phosphorylation
Y84 Phosphorylation
Y85 Phosphorylation
S87 Phosphorylation
Y91 Phosphorylation
Y162 Phosphorylation
Y186 Phosphorylation
K192 Ubiquitination
Y197 Phosphorylation
Y204 Phosphorylation
T210 Phosphorylation
Y227 Phosphorylation
T229 Phosphorylation
K235 Ubiquitination
T241 Phosphorylation
K248 Ubiquitination
K254 Ubiquitination
Y263 Phosphorylation
Y281 Phosphorylation
K290 Ubiquitination
K295 Ubiquitination
K316 Acetylation
C326 S-Nitrosylation
K359 Ubiquitination
K364 Ubiquitination
K371 Ubiquitination
T372 Phosphorylation
K395 Ubiquitination
Y405 Phosphorylation
S430 Phosphorylation
K438 Ubiquitination
K465 Ubiquitination
K470 Ubiquitination
Y473 Phosphorylation
K479 Ubiquitination
K483 Ubiquitination
K520 Ubiquitination
K521 Ubiquitination
S527 Phosphorylation
K545 Ubiquitination
K552 Ubiquitination
Y554 Phosphorylation
K557 Ubiquitination
S562 Phosphorylation
K597 Ubiquitination
K609 Ubiquitination
K642 Ubiquitination
K656 Ubiquitination
Y727 Phosphorylation
Y732 Phosphorylation
Y733 Phosphorylation
K740 Ubiquitination
S752 Phosphorylation
K754 Ubiquitination
K796 Acetylation
K796 Ubiquitination
K811 Acetylation
K811 Ubiquitination

研究背景

功能:

Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

翻译修饰:

Phosphorylated. Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A (By similarity).

亚基结构:

Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.

蛋白家族:

Belongs to the glycogen phosphorylase family.

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Endocrine system > Insulin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

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