NSDHL Antibody - #DF12432

(2)  
产品: NSDHL 抗体
货号: DF12432
描述: Rabbit polyclonal antibody to NSDHL
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 42 kDa,40 kDa; 42kD(Calculated).
蛋白号: Q15738
RRID: AB_2845237

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WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(92%), Bovine(92%), Horse(83%), Sheep(92%), Rabbit(100%), Dog(100%), Chicken(92%)
克隆:
Polyclonal
特异性:
NSDHL Antibody detects endogenous levels of total NSDHL.
RRID:
AB_2845237
引用格式: Affinity Biosciences Cat# DF12432, RRID:AB_2845237.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

decarboxylating; H105E3; H105e3 protein; NAD(P) dependent steroid dehydrogenase like; NSDHL; NSDHL_HUMAN; Protein H105e3; SDR31E1; Short chain dehydrogenase/reductase family 31E member 1; Sterol 4 alpha carboxylate 3 dehydrogenase decarboxylating; Sterol-4-alpha-carboxylate 3-dehydrogenase; XAP104;

抗原和靶标

免疫原:
Uniprot:

Q15738(NSDHL_HUMAN) >>Visit HPA database.

基因/基因ID:
NSDHL(50814)
表达:
Q15738 NSDHL_HUMAN:

Brain, heart, liver, lung, kidney, skin and placenta.

序列:
MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAMERTVQSFRHLRRVK

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Dog
100
Rabbit
100
Bovine
92
Sheep
92
Zebrafish
92
Chicken
92
Horse
83
Xenopus
75
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q15738 作为底物

Site PTM Type Enzyme
M1 Acetylation
T19 Phosphorylation
T22 Phosphorylation
K24 Ubiquitination
K31 Ubiquitination
S87 Phosphorylation
K96 Ubiquitination
S106 Phosphorylation
K114 Ubiquitination
K126 Ubiquitination
K133 Ubiquitination
S147 Phosphorylation
Y164 Phosphorylation
K167 Ubiquitination
K176 Ubiquitination
K191 Ubiquitination
K232 Ubiquitination
K263 Ubiquitination
T284 Phosphorylation
Y288 Phosphorylation
K345 Ubiquitination
Y349 Phosphorylation
T354 Phosphorylation

研究背景

功能:

Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.

细胞定位:

Endoplasmic reticulum membrane>Single-pass membrane protein. Lipid droplet.
Note: Trafficking through the Golgi is necessary for ER membrane localization.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Brain, heart, liver, lung, kidney, skin and placenta.

蛋白家族:

Belongs to the 3-beta-HSD family.

研究领域

· Metabolism > Lipid metabolism > Steroid biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

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