PTGES2 Antibody - #DF12712

(3)  
产品: PTGES2 抗体
货号: DF12712
描述: Rabbit polyclonal antibody to PTGES2
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Dog
分子量: 30 kDa; 42kD(Calculated).
蛋白号: Q9H7Z7
RRID: AB_2845673

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Dog(100%)
克隆:
Polyclonal
特异性:
PTGES2 Antibody detects endogenous levels of total PTGES2.
RRID:
AB_2845673
引用格式: Affinity Biosciences Cat# DF12712, RRID:AB_2845673.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PTGES2;

抗原和靶标

免疫原:
Uniprot:

Q9H7Z7(PGES2_HUMAN) >>Visit HPA database.

基因/基因ID:
PTGES2(80142)
表达:
Q9H7Z7 PGES2_HUMAN:

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

序列:
MDPAARVVRALWPGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGPSPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAAQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVRRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Chicken
67
Zebrafish
58
Sheep
0
Xenopus
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9H7Z7 作为底物

Site PTM Type Enzyme
S46 Phosphorylation
K53 Acetylation
T75 Phosphorylation
S90 Phosphorylation
S95 Phosphorylation
S97 Phosphorylation
T109 Phosphorylation
K115 Ubiquitination
Y127 Phosphorylation
K141 Ubiquitination
K147 Ubiquitination
Y188 Phosphorylation
K193 Ubiquitination
K200 Ubiquitination
T203 Phosphorylation
K208 Ubiquitination
Y209 Phosphorylation
K216 Ubiquitination
K225 Ubiquitination
K233 Ubiquitination
S260 Phosphorylation
Y263 Phosphorylation
K269 Ubiquitination
Y280 Phosphorylation
Y287 Phosphorylation
S290 Phosphorylation
Y308 Phosphorylation
K313 Ubiquitination
T371 Phosphorylation
S374 Phosphorylation

研究背景

功能:

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

细胞定位:

Golgi apparatus membrane>Single-pass membrane protein.

Cytoplasm>Perinuclear region.
Note: Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

亚基结构:

Homodimer. May interact with CEBPB (By similarity). Interacts with EXOSC10.

蛋白家族:

Belongs to the GST superfamily.

研究领域

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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