Syntaxin4 Antibody - #DF12761

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产品: Syntaxin4 抗体
货号: DF12761
描述: Rabbit polyclonal antibody to Syntaxin4
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 35 kDa, 40 kDa; 34kD(Calculated).
蛋白号: Q12846
RRID: AB_2845722

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(92%)
克隆:
Polyclonal
特异性:
Syntaxin4 Antibody detects endogenous levels of total Syntaxin4.
RRID:
AB_2845722
引用格式: Affinity Biosciences Cat# DF12761, RRID:AB_2845722.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

NY REN 31 antigen; p35 2; PLACENTAL; Renal carcinoma antigen NY REN 31; Renal carcinoma antigen NY-REN-31; Stx4; STX4_HUMAN; STX4A; Syntaxin 4; syntaxin 4A (placental); Syntaxin 4A; Syntaxin-4;

抗原和靶标

免疫原:
Uniprot:

Q12846(STX4_HUMAN) >>Visit HPA database.

基因/基因ID:
STX4(6810)
表达:
Q12846 STX4_HUMAN:

Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

序列:
MRDRTHELRQGDDSSDEEDKERVALVVHPGTARLGSPDEEFFHKVRTIRQTIVKLGNKVQELEKQQVTILATPLPEESMKQELQNLRDEIKQLGREIRLQLKAIEPQKEEADENYNSVNTRMRKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHDIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKTALENQKKARKKKVLIAICVSITVVLLAVIIGVTVVG

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Rabbit
100
Dog
92
Zebrafish
50
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q12846 作为底物

Site PTM Type Enzyme
Phosphorylation
S14 Phosphorylation
S15 Phosphorylation
T31 Phosphorylation
S36 Phosphorylation
K44 Ubiquitination
T51 Phosphorylation
K54 Ubiquitination
K58 Ubiquitination
K64 Ubiquitination
T72 Phosphorylation
S78 Phosphorylation
K80 Ubiquitination
K91 Ubiquitination
K102 Ubiquitination
K108 Ubiquitination
Y115 Phosphorylation
S117 Phosphorylation
T120 Phosphorylation
K124 Ubiquitination
T125 Phosphorylation
K140 Ubiquitination
S169 Phosphorylation
S204 Phosphorylation
S208 Phosphorylation
K243 Ubiquitination
S248 Phosphorylation
Y251 Phosphorylation
K260 Ubiquitination

研究背景

功能:

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones.

细胞定位:

Cell membrane>Single-pass type IV membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

亚基结构:

Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that interacts with SYT7 during lysosomal exocytosis. Found in a complex with VAMP8 and SNAP23. Detected in a complex with SNAP23 and STXBP4. Interacts with VAMP2. Interacts with SNAP23 and SNAPIN. Interacts with LLGL1. Interacts (via C-terminus) with CENPF. Interacts with DOC2B. Interacts with STXBP6. Interacts with STXBP3; excludes interaction with DOC2B and SNAP25. Interacts with STXBP4; excludes interaction with VAMP2 (By similarity). Interacts with STXBP5L (By similarity).

蛋白家族:

Belongs to the syntaxin family.

研究领域

· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.

· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.

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