DTX4 Antibody - #DF12963

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产品: DTX4 抗体
货号: DF12963
描述: Rabbit polyclonal antibody to DTX4
应用: WB IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 67 kDa; 67kD(Calculated).
蛋白号: Q9Y2E6
RRID: AB_2845924

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(92%), Dog(92%), Chicken(92%)
克隆:
Polyclonal
特异性:
DTX4 Antibody detects endogenous levels of total DTX4.
RRID:
AB_2845924
引用格式: Affinity Biosciences Cat# DF12963, RRID:AB_2845924.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Deltex4; Dtx4; DTX4_HUMAN; E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING finger protein 155; RNF155;

抗原和靶标

免疫原:
Uniprot:

Q9Y2E6(DTX4_HUMAN) >>Visit HPA database.

基因/基因ID:
DTX4(23220)
序列:
MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTAQEKD

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Pig
92
Dog
92
Chicken
92
Rabbit
92
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9Y2E6 作为底物

Site PTM Type Enzyme
T243 Phosphorylation
T245 Phosphorylation
T270 Phosphorylation
S311 Phosphorylation
T315 Phosphorylation
S376 Phosphorylation
Y447 Phosphorylation
Y453 Phosphorylation
Y505 Phosphorylation
S506 Phosphorylation

研究背景

功能:

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with NLRP4.

蛋白家族:

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.

Belongs to the Deltex family.

研究领域

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

文献引用

1). Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1. Functional & Integrative Genomics (PubMed: 37612343) [IF=2.9]

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