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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Xenopus(92%)
克隆:
Polyclonal
特异性:
MAT2A Antibody detects endogenous levels of total MAT2A.
RRID:
AB_2846099
引用格式: Affinity Biosciences Cat# DF13139, RRID:AB_2846099.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AdoMet synthase 2; AdoMet synthetase 2; AdoMet synthetase; AMS 2; AMS2; MAT 2; MAT 2A; MAT II; MAT-II; Mat2a; MATA 2; MATA2; MATII; Methionine adenosyltransferase 2; Methionine adenosyltransferase; Methionine adenosyltransferase II alpha; Methionine adenosyltransferase II; METK2_HUMAN; S adenosylmethionine synthetase gamma form; S adenosylmethionine synthetase isoform type 2; S-adenosylmethionine synthase isoform type-2; SAMS 2; SAMS2;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
P31153 METK2_HUMAN:

Detected in kidney.

序列:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
92
Chicken
67
Pig
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P31153 作为底物

Site PTM Type Enzyme
K53 Ubiquitination
K61 Ubiquitination
K81 Acetylation
K81 Ubiquitination
K88 Acetylation
K88 Ubiquitination
K97 Ubiquitination
Y101 Phosphorylation
K102 Ubiquitination
C104 S-Nitrosylation
S114 Phosphorylation
K163 Ubiquitination
R192 Methylation
K228 Ubiquitination
K234 Acetylation
K234 Ubiquitination
Y235 Phosphorylation
Y242 Phosphorylation
T262 Phosphorylation
K285 Ubiquitination
K289 Ubiquitination
S293 Phosphorylation
K303 Ubiquitination
K307 Ubiquitination
S319 Phosphorylation
Y320 Phosphorylation
K340 Sumoylation
K350 Ubiquitination
K351 Ubiquitination
K367 Ubiquitination
K368 Sumoylation
K368 Ubiquitination
Y377 Phosphorylation
S384 Phosphorylation
K394 Sumoylation

研究背景

功能:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

组织特异性:

Detected in kidney.

亚基结构:

Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain.

蛋白家族:

Belongs to the AdoMet synthase family.

研究领域

· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Biosynthesis of amino acids.

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