Myelin PLP Antibody - #DF13282

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产品: Myelin PLP 抗体
货号: DF13282
描述: Rabbit polyclonal antibody to Myelin PLP
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog
分子量: 30kDa; 30kD(Calculated).
蛋白号: P60201
RRID: AB_2846301

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
Myelin PLP Antibody detects endogenous levels of total Myelin PLP.
RRID:
AB_2846301
引用格式: Affinity Biosciences Cat# DF13282, RRID:AB_2846301.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HLD1; Lipophilin; Major myelin proteolipid protein; MMPL; Myelin proteolipid protein; MYPR_HUMAN; PLP 1; PLP; PLP/DM20; PLP1; PMD; Proteolipid protein 1; SPG2;

抗原和靶标

免疫原:
Uniprot:

P60201(MYPR_HUMAN) >>Visit HPA database.

基因/基因ID:
PLP1(5354)
序列:
MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
50
Horse
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P60201 作为底物

Site PTM Type Enzyme
S114 Phosphorylation
T116 Phosphorylation
T118 Phosphorylation

研究背景

功能:

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

细胞定位:

Cell membrane>Multi-pass membrane protein. Myelin membrane.
Note: Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
蛋白家族:

Belongs to the myelin proteolipid protein family.

文献引用

1). Proteomic analysis of the effects of caffeine in a neonatal rat model of hypoxic‐ischemic white matter damage. CNS Neuroscience & Therapeutics, 2022 (PubMed: 35393758) [IF=5.5]

Application: WB    Species: Rat    Sample: brain tissue

FIGURE 3 Caffeine improved myelin development after hypoxic‐ischemic WMD in neonatal rats. (A) Western blot detection of MBP, PLP, and MAG. Relative protein levels of (B) MBP, (C) PLP, and (D) MAG. (E) Immunohistochemical staining of MBP and LFB staining in the corpus callosum (CC) area of the ligated side cerebral hemisphere at 14 days after hypoxic‐ischemia (MBP scale bar = 50 μm; LBF scale bar = 50 μm). Average optical density (AOD) values of (F) MBP and (G) LBF staining. (H) Diagrammatic representation of the brain region analyzed for the level of MBP and LBF staining. Data are presented as means ± SEMs. Statistical analyses involved one‐way ANOVA, followed by Tukey's test. *p < 0.05, **p < 0.01, ***p < 0.001. Sham group (n = 6); HI group (n = 6); Caffeine group (n = 6); and Caffeine+AK‐7 group (n = 6). Ca, Caffeine group; Ca+AK‐7, Caffeine+AK‐7 group
2). Identification and preliminary analysis of hub genes associated with bladder cancer progression by comprehensive bioinformatics analysis. Scientific reports, 2024 (PubMed: 38307969) [IF=4.6]

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