产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13397, RRID:AB_2846416.
展开/折叠
Htrp 3; Htrp3; MGC124333; Mtrp3; Receptor activated cation channel TRP3; Short transient receptor potential channel 3; Transient receptor potential cation channel subfamily C member 3; transient receptor potential cation channel subfamily C member 3 variant c; Transient receptor potential channel 3; TRANSIENT RECEPTOR POTENTIAL DROSOPHILA HOMOLOG OF 3; Transient receptor protein 3; Trp related protein 3; TRP3; TrpC3; Trrp3;
抗原和靶标
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
- Q13507 TRPC3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13507 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y37 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | Uniprot | |
| Y138 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| Y214 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| S295 | Phosphorylation | Uniprot | |
| N404 | N-Glycosylation | Uniprot | |
| Y543 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| S696 | Phosphorylation | Uniprot | |
| S700 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S703 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| Y706 | Phosphorylation | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| S800 | Phosphorylation | Uniprot | |
| Y804 | Phosphorylation | Uniprot | |
| S831 | Phosphorylation | Uniprot |
研究背景
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Membrane>Multi-pass membrane protein.
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation.
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily.
研究领域
· Organismal Systems > Development > Axon guidance. (View pathway)
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