| 产品: | TEA domain family member 2 抗体 |
| 货号: | DF13565 |
| 描述: | Rabbit polyclonal antibody to TEA domain family member 2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 49kDa; 49kD(Calculated). |
| 蛋白号: | Q15562 |
| RRID: | AB_2846584 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13565, RRID:AB_2846584.
展开/折叠
Embryonic TEA domain containing factor; Etdf; ETEF 1; ETF; TEA domain family member 2; TEAD 2; TEAD-2; TEAD2; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b); TEAD2_HUMAN; TEF 4; TEF4; Transcriptional enhancer factor 4; Transcriptional enhancer factor TEF 4; Transcriptional enhancer factor TEF-4;
抗原和靶标
- Q15562 TEAD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15562 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K67 | Ubiquitination | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| Y86 | Phosphorylation | Uniprot | |
| K93 | Methylation | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| S112 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| T131 | Phosphorylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| Y275 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K352 | Ubiquitination | Uniprot |
研究背景
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Nucleus.
Interacts with YAP1 and WWTR1/TAZ.
研究领域
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species. (View pathway)
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