产品: TBKBP1 抗体
货号: DF13686
描述: Rabbit polyclonal antibody to TBKBP1
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog, Xenopus
分子量: 67kDa; 68kD(Calculated).
蛋白号: A7MCY6
RRID: AB_2846705

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(86%)
克隆:
Polyclonal
特异性:
TBKBP1 Antibody detects endogenous levels of total TBKBP1.
RRID:
AB_2846705
引用格式: Affinity Biosciences Cat# DF13686, RRID:AB_2846705.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

KIAA0775; ProSAPiP2; SINTBAD; TANK binding kinase 1 binding protein 1; TANK-binding kinase 1-binding protein 1; TBK1 binding protein 1; TBK1-binding protein 1; TBKB1_HUMAN; Tbkbp1;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
A7MCY6 TBKB1_HUMAN:

Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.

序列:
MESMFEDDISILTQEALGPSEVWLDSPGDPSLGGDMCSASHFALITAYGDIKERLGGLERENATLRRRLKVYEIKYPLISDFGEEHGFSLYEIKDGSLLEVEKVSLQQRLNQFQHELQKNKEQEEQLGEMIQAYEKLCVEKSDLETELREMRALVETHLRQICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASNQSERDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPPPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAYGSELYGPGRPLSPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTIRCASFCAGFPIPESPAATAYAHAEHAQSWPSINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
86
Zebrafish
63
Horse
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - A7MCY6 作为底物

Site PTM Type Enzyme
S10 Phosphorylation
T13 Phosphorylation
Y48 Phosphorylation
K70 Ubiquitination
S97 Phosphorylation
K103 Ubiquitination
S105 Phosphorylation
K119 Ubiquitination
K121 Ubiquitination
S184 Phosphorylation
K262 Ubiquitination
K285 Ubiquitination
S335 Phosphorylation
S349 Phosphorylation
S351 Phosphorylation
S365 Phosphorylation
S372 Phosphorylation
S379 Phosphorylation
S385 Phosphorylation
S388 Phosphorylation
S390 Phosphorylation
S393 Phosphorylation
S400 Phosphorylation
S405 Phosphorylation
S415 Phosphorylation
T485 Phosphorylation
S504 Phosphorylation
R513 Methylation
S521 Phosphorylation
S534 Phosphorylation

研究背景

功能:

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

组织特异性:

Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.

亚基结构:

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.

(Microbial infection) Interacts with vaccinia virus protein C6.

研究领域

· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway.   (View pathway)

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