产品: 磷酸化 SNAP23 (Ser95) 抗体
货号: AF3788
描述: Rabbit polyclonal antibody to Phospho-SNAP23 (Ser95)
应用: ELISA(peptide)
反应: Human, Mouse, Rat
分子量: 23kD(Calculated).
蛋白号: O00161
RRID: AB_2847102

浏览相似产品>>

   规格 价格 库存
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

货期: 当天发货

联系销售

产品描述

来源:
Rabbit
应用:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
Phospho-SNAP23 (Ser95) Antibody detects endogenous levels of SNAP23 only when phosphorylated at Ser95.
RRID:
AB_2847102
引用格式: Affinity Biosciences Cat# AF3788, RRID:AB_2847102.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

HsT17016; LS-B8340; SNAP 23; SNAP-23; SNAP23; SNAP23A; SNAP23B; SNP23_HUMAN; Synaptosomal associated protein 23; Synaptosomal associated protein 23kDa; Synaptosomal associated protein; Synaptosomal-associated protein 23; Vesicle membrane fusion protein SNAP 23; Vesicle membrane fusion protein SNAP23; Vesicle-membrane fusion protein SNAP-23;

抗原和靶标

免疫原:

A synthesized peptide derived from human SNAP23 around the phosphorylation site of Ser95.

Uniprot:
基因/基因ID:
表达:
O00161 SNP23_HUMAN:

Ubiquitous. Highest levels where found in placenta.

序列:
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS

翻译修饰 - O00161 作为底物

Site PTM Type Enzyme
M1 Acetylation
S5 Phosphorylation
S6 Phosphorylation
T17 Phosphorylation
S20 Phosphorylation
S23 Phosphorylation P17252 (PRKCA)
T24 Phosphorylation P17252 (PRKCA)
S34 Phosphorylation
K40 Ubiquitination
K49 Ubiquitination
K64 Ubiquitination
K71 Ubiquitination
T72 Phosphorylation
K91 Ubiquitination
S95 Phosphorylation P14618 (PKM)
K97 Ubiquitination
Y99 Phosphorylation
K100 Ubiquitination
T102 Phosphorylation
S110 Phosphorylation
C112 S-Nitrosylation
K117 Ubiquitination
S136 Phosphorylation
Y139 Phosphorylation
K141 Ubiquitination
T144 Phosphorylation
T157 Phosphorylation
S161 Phosphorylation P17252 (PRKCA)
K185 Ubiquitination
K190 Ubiquitination

研究背景

功能:

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

细胞定位:

Cell membrane>Peripheral membrane protein. Cell membrane>Lipid-anchor. Cell junction>Synapse>Synaptosome.
Note: Mainly localized to the plasma membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous. Highest levels where found in placenta.

亚基结构:

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Found in a complex with VAMP8 and STX1A. Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats).

蛋白家族:

Belongs to the SNAP-25 family.

研究领域

· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.

· Organismal Systems > Immune system > Platelet activation.   (View pathway)

限制条款

产品的规格、报价、验证数据请以官网为准,官网链接:www.affbiotech.com | www.affbiotech.cn(简体中文)| www.affbiotech.jp(日本語)

产品的数据信息为Affinity所有,未经授权不得收集Affinity官网数据或资料用于商业用途,对抄袭产品数据的行为我们将保留诉诸法律的权利。

产品相关数据会因产品批次、产品检测情况随时调整,如您已订购该产品,请以订购时随货说明书为准,否则请以官网内容为准,官网内容有改动时恕不另行通知。

Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时,请您在Affinity官方渠道提交售后申请。

产品仅供科学研究使用。不用于诊断和治疗。 

产品未经授权不得转售。

Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.