产品: 磷酸化 p23 (Ser113) 抗体
货号: AF3794
描述: Rabbit polyclonal antibody to Phospho-p23 (Ser113)
应用: IF/ICC
反应: Human, Mouse, Rat
分子量: 19kD(Calculated).
蛋白号: Q15185
RRID: AB_2847108

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产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
Phospho-p23 (Ser113) Antibody detects endogenous levels of p23 only when phosphorylated at Ser113.
RRID:
AB_2847108
引用格式: Affinity Biosciences Cat# AF3794, RRID:AB_2847108.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Co chaperone p23; cPGES; Cytosolic prostaglandin E synthase; Cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; P23; Progesterone receptor complex; Progesterone receptor complex p23; Prostaglandin E synthase 3 (cytosolic); Prostaglandin E synthase 3; PTGES 3; PTGES3; Sid 3177; TEBP; TEBP_HUMAN; Telomerase binding protein p23; Telomerase-binding protein p23; Unactive progesterone receptor 23 kD;

抗原和靶标

免疫原:

A synthesized peptide derived from human p23 around the phosphorylation site of Ser113.

Uniprot:
基因/基因ID:
序列:
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE

翻译修饰 - Q15185 作为底物

Site PTM Type Enzyme
K7 Acetylation
K7 Ubiquitination
Y14 Phosphorylation
K33 Acetylation
K33 Methylation
K33 Sumoylation
K33 Ubiquitination
K35 Acetylation
K35 Sumoylation
K35 Ubiquitination
S39 Phosphorylation
C40 S-Nitrosylation
S44 Phosphorylation
K48 Acetylation
K48 Methylation
K48 Ubiquitination
C58 S-Nitrosylation
S64 Phosphorylation
K65 Sumoylation
K65 Ubiquitination
K67 Ubiquitination
S72 Phosphorylation
C75 S-Nitrosylation
C76 S-Nitrosylation
K79 Sumoylation
K79 Ubiquitination
S82 Phosphorylation
S85 Phosphorylation
K91 Acetylation
K91 Ubiquitination
K95 Sumoylation
K95 Ubiquitination
S100 Phosphorylation
S113 Phosphorylation P68400 (CSNK2A1)
S118 Phosphorylation P68400 (CSNK2A1)
S124 Phosphorylation
S148 Phosphorylation
S151 Phosphorylation

研究背景

功能:

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Binds to the progesterone receptor. Interacts with TERT; the interaction, together with HSP90AA1, is required for correct assembly and stabilization of the telomerase holoenzyme complex. Interacts (via PXLE motif) with EGLN1/PHD2, recruiting EGLN1/PHD2 to the HSP90 pathway to facilitate HIF alpha proteins hydroxylation. Interacts with HSP90AA1, FLCN, FNIP1 and FNIP2.

蛋白家族:

The PXLE motif mediates interaction with EGLN1/PHD2.

Belongs to the p23/wos2 family.

研究领域

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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