GRK3 Antibody - #DF3165

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产品: GRK3 抗体
货号: DF3165
描述: Rabbit polyclonal antibody to GRK3
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 80 KD; 80kD(Calculated).
蛋白号: P35626
RRID: AB_2835541

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
克隆:
Polyclonal
特异性:
GRK3 Antibody detects endogenous levels of total GRK3.
RRID:
AB_2835541
引用格式: Affinity Biosciences Cat# DF3165, RRID:AB_2835541.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ADRBK2; Adrenergic, beta, receptor kinase 2; ARBK2_HUMAN; BARK2; Beta adrenergic receptor kinase 2; Beta ARK 2; Beta-adrenergic receptor kinase 2; Beta-ARK-2; EC 2.7.11.15; G protein coupled receptor kinase 3; G-protein-coupled receptor kinase 3; GRK3;

抗原和靶标

免疫原:
Uniprot:

P35626(ARBK2_HUMAN) >>Visit HPA database.

基因/基因ID:
GRK3(157)
序列:
MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRRAPKFLNKPRSGTVELPKPSLCHRNSNGL

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Chicken
100
Rabbit
100
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P35626 作为底物

Site PTM Type Enzyme
K45 Ubiquitination
K57 Ubiquitination
K62 Ubiquitination
K84 Ubiquitination
K90 Ubiquitination
K94 Ubiquitination
Y109 Phosphorylation
Y112 Phosphorylation
K115 Ubiquitination
K126 Ubiquitination
K138 Ubiquitination
K139 Ubiquitination
K164 Ubiquitination
K170 Ubiquitination
Y206 Phosphorylation
T213 Phosphorylation
K215 Ubiquitination
K220 Ubiquitination
K230 Ubiquitination
K319 Ubiquitination
K344 Ubiquitination
K345 Ubiquitination
K346 Ubiquitination
S350 Phosphorylation
T353 Phosphorylation
Y356 Phosphorylation
S423 Phosphorylation
K448 Ubiquitination
K454 Ubiquitination
K465 Ubiquitination
S487 Phosphorylation
K494 Ubiquitination
K497 Ubiquitination
K507 Ubiquitination
S514 Phosphorylation
T524 Phosphorylation
Y526 Phosphorylation
K545 Ubiquitination
Y564 Phosphorylation
T612 Phosphorylation
K625 Acetylation
K628 Acetylation
K628 Ubiquitination
K644 Ubiquitination
K645 Ubiquitination
K652 Ubiquitination
S670 Phosphorylation
T672 Phosphorylation
S685 Phosphorylation

翻译修饰 - P35626 作为激酶

Substrate Site Source
P07550 (ADRB2) S355 Uniprot
P07550 (ADRB2) S356 Uniprot
P21731-2 (TBXA2R) S239 Uniprot
P21731-2 (TBXA2R) S357 Uniprot
P30411 (BDKRB2) S366 Uniprot
P30411 (BDKRB2) S373 Uniprot
P30411 (BDKRB2) S375 Uniprot
P30874 (SSTR2) S341 Uniprot
P30874 (SSTR2) S343 Uniprot
P35372 (OPRM1) T182 Uniprot
P41146 (OPRL1) S363 Uniprot
P51681 (CCR5) S336 Uniprot
P51681 (CCR5) S337 Uniprot
P51681 (CCR5) S342 Uniprot
P51681 (CCR5) S349 Uniprot

研究背景

功能:

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.

翻译修饰:

Ubiquitinated.

蛋白家族:

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway.   (View pathway)

· Human Diseases > Substance dependence > Morphine addiction.

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Nervous system > Glutamatergic synapse.

· Organismal Systems > Sensory system > Olfactory transduction.

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