POLR1C Antibody - #DF4008
| 产品: | POLR1C 抗体 |
| 货号: | DF4008 |
| 描述: | Rabbit polyclonal antibody to POLR1C |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 39 KD; 39kD(Calculated). |
| 蛋白号: | O15160 |
| RRID: | AB_2836368 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF4008, RRID:AB_2836368.
展开/折叠
40kDa; AA409007; AA959927; Ac2-127; AC40; AL024089; DNA directed RNA polymerase I subunit C; DNA directed RNA polymerases I and III 40 kDa polypeptide; DNA directed RNA polymerases I and III subunit RPAC1; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; MGC105583; MGC161175; POLR1C; POLR1E; Polymerase (RNA) I polypeptide C, 30kDa; RNA polymerase 1 1; RNA polymerases I and III subunit AC1; RP3-337H4.4; RPA39; RPA40; RPA5; RPAC1; RPAC1_HUMAN; RPC40; Rpo1 1; TCS3;
抗原和靶标
- O15160 RPAC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENSLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPRLFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGNQADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDITLLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLARVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O15160 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| Y33 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| Y36 | Phosphorylation | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| R120 | Methylation | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| R125 | Methylation | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| C256 | S-Nitrosylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| K332 | Ubiquitination | Uniprot |
研究背景
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
Nucleus.
Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
研究领域
· Genetic Information Processing > Transcription > RNA polymerase.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway. (View pathway)
限制条款
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