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| 产品: | LYVE1 抗体 |
| 货号: | AF4202 |
| 描述: | Rabbit polyclonal antibody to LYVE1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat, Monkey |
| 分子量: | 40 kd; 35kD(Calculated). |
| 蛋白号: | Q9Y5Y7 |
| RRID: | AB_2837586 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4202, RRID:AB_2837586.
展开/折叠
Cell surface retention sequence-binding protein 1; CRSBP 1; CRSBP-1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; HAR; Hyaluronic acid receptor; Lymphatic endothelium specific hyaluronan receptor; lymphatic vessel endothelial hyaluronan receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE 1; LYVE-1; LYVE1; LYVE1_HUMAN; XLKD1;
抗原和靶标
- Q9Y5Y7 LYVE1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEACRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPVSRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTTEFIVSDSTYSVASPYSTIPAPTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTALLVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKANDSNPNEESKKTDKNPEESKSPSKTTVRCLEAEV
翻译修饰 - Q9Y5Y7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T42 | Phosphorylation | Uniprot | |
| N53 | N-Glycosylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| T76 | Phosphorylation | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| K298 | Methylation | Uniprot |
研究背景
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
O-glycosylated.
Membrane>Single-pass type I membrane protein.
Note: Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
Mainly expressed in endothelial cells lining lymphatic vessels.
Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity).
文献引用
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