产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0125, RRID:AB_2833309.
展开/折叠
ARVD 12; ARVD12; Catenin (cadherin associated protein), gamma 80kDa; catenin (cadherin-associated protein) gamma (80kD); Catenin gamma; CTNNG; Desmoplakin 3; Desmoplakin III; Desmoplakin-3; Desmoplakin3; DesmoplakinIII; DP 3; DP III; DP3; DPIII; gamma catenin; Junction plakoglobin; JUP; OTTHUMP00000164732; OTTHUMP00000164735; OTTHUMP00000164738; PDGB; PKGB; PLAK_HUMAN; PLAKOGLOBIN;
抗原和靶标
- P14923 PLAK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDMDGDYPIDTYSDGLRPPYPTADHMLA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P14923 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T14 | O-Glycosylation | Uniprot | |
| T19 | Phosphorylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| T21 | Phosphorylation | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| T54 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| T59 | Phosphorylation | Uniprot | |
| T60 | Phosphorylation | Uniprot | |
| Y61 | Phosphorylation | Uniprot | |
| T62 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| T104 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| K124 | Ubiquitination | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| Y133 | Phosphorylation | P06241 (FYN) | Uniprot |
| T141 | Phosphorylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| S182 | Phosphorylation | Uniprot | |
| T196 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K326 | Acetylation | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| K385 | Ubiquitination | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| K426 | Ubiquitination | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| Y480 | Phosphorylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| T546 | Phosphorylation | Uniprot | |
| Y550 | Phosphorylation | P06241 (FYN) , P16591 (FER) | Uniprot |
| T551 | Phosphorylation | Uniprot | |
| T564 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| Y644 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y660 | Phosphorylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| T669 | Phosphorylation | Uniprot | |
| S671 | Phosphorylation | Uniprot | |
| Y701 | Phosphorylation | Uniprot | |
| Y724 | Phosphorylation | Uniprot | |
| T728 | Phosphorylation | Uniprot | |
| Y729 | Phosphorylation | Uniprot | |
| S730 | Phosphorylation | Uniprot |
研究背景
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
May be phosphorylated by FER.
Cell junction>Adherens junction. Cell junction>Desmosome. Cytoplasm>Cytoskeleton. Membrane>Peripheral membrane protein.
Note: Cytoplasmic in a soluble and membrane-associated form.
Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1 (By similarity). Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2.
The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region.
Belongs to the beta-catenin family.
研究领域
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Human Diseases > Cancers: Specific types > Acute myeloid leukemia. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
限制条款
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