| 产品: | Cholinesterase/BCHE 抗体 |
| 货号: | DF6419 |
| 描述: | Rabbit polyclonal antibody to Cholinesterase/BCHE |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Rabbit |
| 分子量: | 68kDa; 68kD(Calculated). |
| 蛋白号: | P06276 |
| RRID: | AB_2838382 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6419, RRID:AB_2838382.
展开/折叠
Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; CHE1; CHE2; CHLE_HUMAN; Choline esterase II; Cholinesterase (serum) 2; Cholinesterase 1; Cholinesterase; E1; Pseudocholinesterase; Pseudocholinesterase E1;
抗原和靶标
Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
- P06276 CHLE_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P06276 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| N45 | N-Glycosylation | Uniprot | |
| N85 | N-Glycosylation | Uniprot | |
| K88 | Acetylation | Uniprot | |
| N134 | N-Glycosylation | Uniprot | |
| Y174 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| N269 | N-Glycosylation | Uniprot | |
| N284 | N-Glycosylation | Uniprot | |
| N369 | N-Glycosylation | Uniprot | |
| K436 | Methylation | Uniprot | |
| K455 | Methylation | Uniprot | |
| N483 | N-Glycosylation | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| N509 | N-Glycosylation | Uniprot | |
| N513 | N-Glycosylation | Uniprot | |
| N514 | N-Glycosylation | Uniprot |
研究背景
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
N-glycosylated. No other PTM detected. The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type.
Secreted.
Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Homotetramer; disulfide-linked. Dimer of dimers.
Belongs to the type-B carboxylesterase/lipase family.
限制条款
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