产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF6667, RRID:AB_2838629.
展开/折叠
Acid beta galactosidase; Acid beta-galactosidase; Beta galactosidase 1; Beta galactosidase; Beta-galactosidase; BGAL_HUMAN; EBP; EBP, included; Elastin receptor 1 (67kD); Elastin receptor 1 67kDa; Elastin receptor 1; Elastin receptor 1, included; Elastin-binding protein, included; ELNR1; Galactosidase beta 1; GLB 1; GLB1; Lactase; MPS4B; S-GAL, included;
抗原和靶标
Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208).
- P16278 BGAL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGFLVRILPLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
翻译修饰 - P16278 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T21 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| K43 | Methylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| Y57 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| Y154 | Phosphorylation | Uniprot | |
| N247 | N-Glycosylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| K383 | Ubiquitination | Uniprot | |
| N464 | N-Glycosylation | Uniprot | |
| Y485 | Phosphorylation | Uniprot | |
| Y488 | Phosphorylation | Uniprot | |
| K493 | Acetylation | Uniprot | |
| N498 | N-Glycosylation | Uniprot | |
| N555 | N-Glycosylation | Uniprot | |
| K670 | Ubiquitination | Uniprot |
研究背景
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
Lysosome.
Cytoplasm>Perinuclear region.
Note: Localized to the perinuclear area of the cytoplasm but not to lysosomes.
Detected in placenta (at protein level). Detected in fibroblasts and testis.
Homodimer. May form higher multimers (Probable).
Belongs to the glycosyl hydrolase 35 family.
研究领域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Glycan biosynthesis and metabolism > Other glycan degradation.
· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan degradation.
· Metabolism > Lipid metabolism > Sphingolipid metabolism.
· Metabolism > Glycan biosynthesis and metabolism > Glycosphingolipid biosynthesis - ganglio series.
· Metabolism > Global and overview maps > Metabolic pathways.
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