ALDH4A1 Antibody - #DF7044

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产品: ALDH4A1 抗体
货号: DF7044
描述: Rabbit polyclonal antibody to ALDH4A1
应用: WB IHC
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
分子量: 62kDa; 62kD(Calculated).
蛋白号: P30038
RRID: AB_2839000

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(92%), Chicken(83%), Xenopus(92%)
克隆:
Polyclonal
特异性:
ALDH4A1 Antibody detects endogenous levels of total ALDH4A1.
RRID:
AB_2839000
引用格式: Affinity Biosciences Cat# DF7044, RRID:AB_2839000.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AL4A1_HUMAN; aldehyde dehydrogenase 4; aldehyde dehydrogenase 4 family, member A1; Aldehyde dehydrogenase family 4 member A1; Aldehyde dehydrogenase, family 4, subfamily A, member 1; ALDH4; aldh4a1; Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial; Delta-1-pyrroline-5-carboxylate dehydrogenase; L-glutamate gamma-semialdehyde dehydrogenase; mitochondrial; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C dehydrogenase; P5CD; P5CDh; P5CDhL; P5CDhS; Pyrroline-5-carboxylate dehydrogenase; RP11 128M10.1;

抗原和靶标

免疫原:
Uniprot:

P30038(AL4A1_HUMAN) >>Visit HPA database.

基因/基因ID:
ALDH4A1(8659)
表达:
P30038 AL4A1_HUMAN:

Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.

描述:
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
序列:
MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYAYMQ

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Zebrafish
100
Xenopus
92
Rabbit
92
Chicken
83
Pig
0
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P30038 作为底物

Site PTM Type Enzyme
S44 Phosphorylation
K93 Acetylation
Y96 Phosphorylation
K153 Methylation
R304 Methylation
S326 Phosphorylation
S331 Phosphorylation
T336 Phosphorylation
K462 Acetylation
K495 Methylation
K495 Ubiquitination
R498 Methylation
Y505 Phosphorylation
T528 Phosphorylation
K552 Acetylation

研究背景

功能:

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.

细胞定位:

Mitochondrion matrix.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.

亚基结构:

Homodimer.

蛋白家族:

Belongs to the aldehyde dehydrogenase family.

研究领域

· Metabolism > Amino acid metabolism > Alanine, aspartate and glutamate metabolism.

· Metabolism > Amino acid metabolism > Arginine and proline metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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