ATIC Antibody - #DF7399

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产品: ATIC 抗体
货号: DF7399
描述: Rabbit polyclonal antibody to ATIC
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 64kDa; 65kD(Calculated).
蛋白号: P31939
RRID: AB_2839337

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(86%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
ATIC Antibody detects endogenous levels of total ATIC.
RRID:
AB_2839337
引用格式: Affinity Biosciences Cat# DF7399, RRID:AB_2839337.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AICAR formyltransferase/IMP cyclohydrolase; 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase; 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICARFT; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; FLJ93545; HEL-S-70p; IMP cyclohydrolase; IMP synthase; IMP synthetase; IMPCHASE; Inosinicase; OK/SW-cl.86; Phosphoribosylaminoimidazolecarboxamide formyltransferase; Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PUR9_HUMAN; PURH;

抗原和靶标

免疫原:
Uniprot:

P31939(PUR9_HUMAN) >>Visit HPA database.

基因/基因ID:
ATIC(471)
描述:
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
序列:
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
86
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P31939 作为底物

Site PTM Type Enzyme
M1 Acetylation
K14 Ubiquitination
T25 Phosphorylation
S34 Phosphorylation
T37 Phosphorylation
K39 Ubiquitination
R42 Methylation
S52 Phosphorylation
K66 Ubiquitination
R79 Methylation
Y104 Phosphorylation Q9UM73 (ALK)
K108 Ubiquitination
S112 Phosphorylation
K137 Ubiquitination
T166 Phosphorylation
K177 Ubiquitination
T180 Phosphorylation
T182 Phosphorylation
S190 Phosphorylation
Y192 Phosphorylation
K199 Acetylation
K199 Ubiquitination
Y208 Phosphorylation
Y220 Phosphorylation
K254 Ubiquitination
S264 Phosphorylation
K266 Acetylation
K266 Ubiquitination
S269 Phosphorylation
S280 Phosphorylation
K285 Ubiquitination
Y290 Phosphorylation
Y293 Phosphorylation
K294 Ubiquitination
T295 Phosphorylation
T297 Phosphorylation
S300 Phosphorylation
Y303 Phosphorylation
R305 Methylation
K331 Ubiquitination
S338 Phosphorylation
S355 Phosphorylation
K356 Acetylation
K356 Ubiquitination
K357 Ubiquitination
K372 Ubiquitination
S387 Phosphorylation
K389 Ubiquitination
K397 Ubiquitination
S398 Phosphorylation
S401 Phosphorylation
T405 Phosphorylation
K406 Ubiquitination
K408 Ubiquitination
S413 Phosphorylation
T422 Phosphorylation
C434 S-Nitrosylation
K437 Ubiquitination
K461 Ubiquitination
Y464 Phosphorylation
K477 Ubiquitination
K507 Sumoylation
K507 Ubiquitination
K509 Sumoylation
K509 Ubiquitination
T520 Phosphorylation
K524 Ubiquitination
S537 Phosphorylation

研究背景

功能:

Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.

Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.

亚基结构:

Homodimer. Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis.

蛋白家族:

The IMP cyclohydrolase activity resides in the N-terminal region.

Belongs to the PurH family.

研究领域

· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Metabolism > Metabolism of cofactors and vitamins > One carbon pool by folate.

· Metabolism > Global and overview maps > Metabolic pathways.

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