PSME2 Antibody - #DF7402

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产品: PSME2 抗体
货号: DF7402
描述: Rabbit polyclonal antibody to PSME2
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 27kDa; 27kD(Calculated).
蛋白号: Q9UL46
RRID: AB_2839340

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(89%)
克隆:
Polyclonal
特异性:
PSME2 Antibody detects endogenous levels of total PSME2.
RRID:
AB_2839340
引用格式: Affinity Biosciences Cat# DF7402, RRID:AB_2839340.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Cell migration inducing protein 22; MCP activator 31 kD subunit; PA28 beta; PA28b; PA28beta; Proteasome (prosome macropain) activator subunit 2 (PA28 beta); Proteasome (prosome macropain) activator subunit 2; Proteasome activator 28 beta; Proteasome activator 28 subunit beta; Proteasome activator complex subunit 2; Proteasome activator hPA28 subunit beta; Proteasome activator subunit 2; PSME 2; PSME2; PSME2_HUMAN; REG beta; REG-beta; REGbeta;

抗原和靶标

免疫原:
Uniprot:

Q9UL46(PSME2_HUMAN) >>Visit HPA database.

基因/基因ID:
PSME2(5721)
描述:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
序列:
MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Rabbit
100
Xenopus
89
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UL46 作为底物

Site PTM Type Enzyme
A2 Acetylation
K3 Methylation
K3 Ubiquitination
R8 Methylation
S10 Phosphorylation
K15 Ubiquitination
K39 Ubiquitination
S102 Phosphorylation
K108 Ubiquitination
K115 Ubiquitination
K145 Ubiquitination
T162 Phosphorylation
K166 Ubiquitination
K180 Acetylation
Y199 Phosphorylation
Y217 Phosphorylation
K235 Ubiquitination
Y239 Phosphorylation

研究背景

功能:

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

亚基结构:

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

蛋白家族:

Belongs to the PA28 family.

研究领域

· Genetic Information Processing > Folding, sorting and degradation > Proteasome.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

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