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| 产品: | ANPEP/CD13 抗体 |
| 货号: | DF7445 |
| 描述: | Rabbit polyclonal antibody to ANPEP/CD13 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 109kDa; 110kD(Calculated). |
| 蛋白号: | P15144 |
| RRID: | AB_2839383 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7445, RRID:AB_2839383.
展开/折叠
Alanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; AMPN_HUMAN; ANPEP; AP M; AP N; AP-M; AP-N; APN; CD 13; CD13; CD13 antigen; gp150; hAPN; LAP 1; LAP1; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; p150; PEPN;
抗原和靶标
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
- P15144 AMPN_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P15144 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y6 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| N128 | N-Glycosylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| T209 | Phosphorylation | Uniprot | |
| N234 | N-Glycosylation | Uniprot | |
| N265 | N-Glycosylation | Uniprot | |
| N319 | N-Glycosylation | Uniprot | |
| Y441 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| T457 | Phosphorylation | Uniprot | |
| S460 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| N527 | N-Glycosylation | Uniprot | |
| N573 | N-Glycosylation | Uniprot | |
| Y582 | Phosphorylation | Uniprot | |
| T589 | Phosphorylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| Y600 | Phosphorylation | Uniprot | |
| N625 | N-Glycosylation | Uniprot | |
| S670 | Phosphorylation | Uniprot | |
| N681 | N-Glycosylation | Uniprot | |
| T727 | Phosphorylation | Uniprot | |
| N818 | N-Glycosylation | Uniprot | |
| Y913 | Phosphorylation | Uniprot | |
| T928 | Phosphorylation | Uniprot | |
| S932 | Phosphorylation | Uniprot | |
| T934 | Phosphorylation | Uniprot |
研究背景
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
Sulfated.
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form.
Cell membrane>Single-pass type II membrane protein.
Note: Also found as a soluble form.
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Homodimer. Interacts with SLC6A19 (By similarity).
(Microbial infection) Interacts with the S1 domain of human coronavirus 229E/HCoV-229E spike protein.
Belongs to the peptidase M1 family.
研究领域
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Renin-angiotensin system. (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
文献引用
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