KCNN1 Antibody - #DF2237

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产品: KCNN1 抗体
货号: DF2237
描述: Rabbit polyclonal antibody to KCNN1
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Horse, Sheep, Dog
分子量: 60 kDa; 60kD(Calculated).
蛋白号: Q92952
RRID: AB_2839468

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(92%), Horse(92%), Sheep(100%), Dog(92%)
克隆:
Polyclonal
特异性:
KCNN1 Antibody detects endogenous levels of total KCNN1.
RRID:
AB_2839468
引用格式: Affinity Biosciences Cat# DF2237, RRID:AB_2839468.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

hSK1; KCa2.1; KCNN 1; Kcnn1; KCNN1_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 1; SK; SK1; SKCa 1; SKCa1; Small conductance calcium activated potassium channel protein 1; Small conductance calcium-activated potassium channel protein 1;

抗原和靶标

免疫原:
Uniprot:

Q92952(KCNN1_HUMAN) >>Visit HPA database.

基因/基因ID:
KCNN1(3780)
描述:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin
序列:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Sheep
100
Pig
92
Horse
92
Dog
92
Chicken
77
Bovine
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q92952 作为底物

Site PTM Type Enzyme
S16 Phosphorylation
S107 Phosphorylation
Y109 Phosphorylation P00533 (EGFR)
K373 Ubiquitination
T409 Phosphorylation

研究背景

功能:

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

细胞定位:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

蛋白家族:

Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

研究领域

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

文献引用

1). Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing. Journal of Psychiatric Research (PubMed: 37216772) [IF=4.8]

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