TAF15 Antibody - #DF2424

(1)  
产品: TAF15 抗体
货号: DF2424
描述: Rabbit polyclonal antibody to TAF15
应用: WB
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 62 kDa; 62kD(Calculated).
蛋白号: Q92804
RRID: AB_2839630

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%)
克隆:
Polyclonal
特异性:
TAF15 Antibody detects endogenous levels of total TAF15.
RRID:
AB_2839630
引用格式: Affinity Biosciences Cat# DF2424, RRID:AB_2839630.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

68 kDa TATA-binding protein-associated factor; Npl3; RBP56; RBP56_HUMAN; RNA binding protein 56; RNA-binding protein 56; TAF; TAF(II)68; TAF15; TAF15 RNA polymerase II TATA box binding protein (TBP) associated factor 68kDa; TAF2N; TAFII68; TATA-binding protein-associated factor 2N;

抗原和靶标

免疫原:
Uniprot:

Q92804(RBP56_HUMAN) >>Visit HPA database.

基因/基因ID:
TAF15(8148)
表达:
Q92804 RBP56_HUMAN:

Ubiquitous. Observed in all fetal and adult tissues.

描述:
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
序列:
MSDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRNDYRNDQRNRPY

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Chicken
100
Rabbit
100
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q92804 作为底物

Site PTM Type Enzyme
Y50 Phosphorylation
Y70 Phosphorylation
S76 Phosphorylation
S77 Phosphorylation
Y78 Phosphorylation
S79 Phosphorylation
Y83 Phosphorylation
S94 Phosphorylation
S95 Phosphorylation
S97 Phosphorylation
S104 Phosphorylation
Y110 Phosphorylation
S115 Phosphorylation
Y116 Phosphorylation
Y135 Phosphorylation
Y142 Phosphorylation
Y149 Phosphorylation
Y156 Phosphorylation
S157 Phosphorylation
T160 Phosphorylation
R164 Methylation
Y170 Phosphorylation
R175 Methylation
Y177 Phosphorylation
S180 Phosphorylation
R185 Methylation
R187 Methylation
Y190 Phosphorylation
K192 Methylation
R195 Methylation
T199 Phosphorylation
S201 Phosphorylation
S202 Phosphorylation
R206 Methylation
K210 Methylation
Y218 Phosphorylation
T222 Phosphorylation
S226 Phosphorylation
S228 Phosphorylation
S231 Phosphorylation
K261 Ubiquitination
K265 Ubiquitination
K268 Acetylation
K268 Ubiquitination
K277 Methylation
K277 Ubiquitination
S289 Phosphorylation
S295 Phosphorylation
K297 Sumoylation
K297 Ubiquitination
K306 Acetylation
K306 Ubiquitination
R320 Methylation
R321 Methylation
R326 Methylation
S330 Phosphorylation
R334 Methylation
R335 Methylation
R349 Methylation
K354 Acetylation
K354 Ubiquitination
S355 Phosphorylation
S375 Phosphorylation
R383 Methylation
S387 Phosphorylation
R388 Methylation
R395 Methylation
R397 Methylation
R403 Methylation
R415 Methylation
Y418 Phosphorylation
R422 Methylation
S423 Phosphorylation
Y427 Phosphorylation
R431 Methylation
S433 Phosphorylation
Y437 Phosphorylation
S438 Phosphorylation
R441 Methylation
S442 Phosphorylation
Y446 Phosphorylation
R450 Methylation
S451 Phosphorylation
Y455 Phosphorylation
R459 Methylation
Y463 Phosphorylation
R467 Methylation
Y471 Phosphorylation
R475 Methylation
Y479 Phosphorylation
R483 Methylation
Y486 Phosphorylation
R490 Methylation
Y494 Phosphorylation
R498 Methylation
Y501 Phosphorylation
R505 Methylation
Y508 Phosphorylation
R512 Methylation
R519 Methylation
R528 Methylation
Y531 Phosphorylation
R535 Methylation
R545 Methylation
R553 Methylation
S554 Phosphorylation
R562 Methylation
R570 Methylation
K576 Methylation
R580 Methylation
Y583 Phosphorylation
R588 Methylation
R590 Methylation

研究背景

功能:

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

翻译修饰:

Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.

ADP-ribosylated during genotoxic stress.

细胞定位:

Nucleus. Cytoplasm.
Note: Shuttles from the nucleus to the cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous. Observed in all fetal and adult tissues.

亚基结构:

Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

蛋白家族:

Belongs to the RRM TET family.

研究领域

· Genetic Information Processing > Transcription > Basal transcription factors.

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

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