| 产品: | UGGT1 抗体 |
| 货号: | DF8205 |
| 描述: | Rabbit polyclonal antibody to UGGT1 |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Zebrafish, Bovine, Horse, Dog |
| 分子量: | 177 kDa; 177kD(Calculated). |
| 蛋白号: | Q9NYU2 |
| RRID: | AB_2841513 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8205, RRID:AB_2841513.
展开/折叠
GT; HUGT1; UDP glucose glycoprotein glucosyltransferase 1; UDP Glucose Glycoprotein Glucosyltransferase; UDP--Glc:glycoprotein glucosyltransferase; UDP-glucose ceramide glucosyltransferase-like 1; UDP-glucose:glycoprotein glucosyltransferase 1; UGCGL1; UGGG1; UGGG1_HUMAN; UGGT; Uggt1; UGT1; UGTR;
抗原和靶标
Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.
- Q9NYU2 UGGG1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGCKGDASGACAAGALPVTGVCYKMGVLVVLTVLWLFSSVKADSKAITTSLTTKWFSTPLLLEASEFLAEDSQEKFWNFVEASQNIGSSDHDGTDYSYYHAILEAAFQFLSPLQQNLFKFCLSLRSYSATIQAFQQIAADEPPPEGCNSFFSVHGKKTCESDTLEALLLTASERPKPLLFKGDHRYPSSNPESPVVIFYSEIGSEEFSNFHRQLISKSNAGKINYVFRHYIFNPRKEPVYLSGYGVELAIKSTEYKAKDDTQVKGTEVNTTVIGENDPIDEVQGFLFGKLRDLHPDLEGQLKELRKHLVESTNEMAPLKVWQLQDLSFQTAARILASPVELALVVMKDLSQNFPTKARAITKTAVSSELRTEVEENQKYFKGTLGLQPGDSALFINGLHMDLDTQDIFSLFDVLRNEARVMEGLHRLGIEGLSLHNVLKLNIQPSEADYAVDIRSPAISWVNNLEVDSRYNSWPSSLQELLRPTFPGVIRQIRKNLHNMVFIVDPAHETTAELMNTAEMFLSNHIPLRIGFIFVVNDSEDVDGMQDAGVAVLRAYNYVAQEVDDYHAFQTLTHIYNKVRTGEKVKVEHVVSVLEKKYPYVEVNSILGIDSAYDRNRKEARGYYEQTGVGPLPVVLFNGMPFEREQLDPDELETITMHKILETTTFFQRAVYLGELPHDQDVVEYIMNQPNVVPRINSRILTAERDYLDLTASNNFFVDDYARFTILDSQGKTAAVANSMNYLTKKGMSSKEIYDDSFIRPVTFWIVGDFDSPSGRQLLYDAIKHQKSSNNVRISMINNPAKEISYENTQISRAIWAALQTQTSNAAKNFITKMAKEGAAEALAAGADIAEFSVGGMDFSLFKEVFESSKMDFILSHAVYCRDVLKLKKGQRAVISNGRIIGPLEDSELFNQDDFHLLENIILKTSGQKIKSHIQQLRVEEDVASDLVMKVDALLSAQPKGDPRIEYQFFEDRHSAIKLRPKEGETYFDVVAVVDPVTREAQRLAPLLLVLAQLINMNLRVFMNCQSKLSDMPLKSFYRYVLEPEISFTSDNSFAKGPIAKFLDMPQSPLFTLNLNTPESWMVESVRTPYDLDNIYLEEVDSVVAAEYELEYLLLEGHCYDITTGQPPRGLQFTLGTSANPVIVDTIVMANLGYFQLKANPGAWILRLRKGRSEDIYRIYSHDGTDSPPDADEVVIVLNNFKSKIIKVKVQKKADMVNEDLLSDGTSENESGFWDSFKWGFTGQKTEEVKQDKDDIINIFSVASGHLYERFLRIMMLSVLKNTKTPVKFWFLKNYLSPTFKEFIPYMANEYNFQYELVQYKWPRWLHQQTEKQRIIWGYKILFLDVLFPLVVDKFLFVDADQIVRTDLKELRDFNLDGAPYGYTPFCDSRREMDGYRFWKSGYWASHLAGRKYHISALYVVDLKKFRKIAAGDRLRGQYQGLSQDPNSLSNLDQDLPNNMIHQVPIKSLPQEWLWCETWCDDASKKRAKTIDLCNNPMTKEPKLEAAVRIVPEWQDYDQEIKQLQIRFQKEKETGALYKEKTKEPSREGPQKREEL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9NYU2 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y96 | Phosphorylation | Uniprot | |
| Y98 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| Y240 | Phosphorylation | Uniprot | |
| Y244 | Phosphorylation | Uniprot | |
| T253 | Phosphorylation | Uniprot | |
| Y255 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K362 | Ubiquitination | Uniprot | |
| K378 | Acetylation | Uniprot | |
| K378 | Ubiquitination | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| Y449 | Phosphorylation | Uniprot | |
| S538 | Phosphorylation | Uniprot | |
| Y565 | Phosphorylation | Uniprot | |
| T580 | Phosphorylation | Uniprot | |
| Y684 | Phosphorylation | Uniprot | |
| Y741 | Phosphorylation | Uniprot | |
| S748 | Phosphorylation | Uniprot | |
| Y779 | Phosphorylation | Uniprot | |
| K930 | Ubiquitination | Uniprot | |
| S955 | Phosphorylation | Uniprot | |
| K959 | Ubiquitination | Uniprot | |
| Y966 | Phosphorylation | Uniprot | |
| R972 | Methylation | Uniprot | |
| S1026 | Phosphorylation | Uniprot | |
| K1034 | Acetylation | Uniprot | |
| R1038 | Methylation | Uniprot | |
| T1145 | Phosphorylation | Uniprot | |
| T1241 | O-Glycosylation | Uniprot | |
| S1277 | Phosphorylation | Uniprot | |
| T1282 | Phosphorylation | Uniprot | |
| K1287 | Ubiquitination | Uniprot | |
| S1296 | Phosphorylation | Uniprot | |
| R1435 | Methylation | Uniprot | |
| Y1516 | Phosphorylation | Uniprot |
研究背景
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.
Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.
Monomer as well as in a tight complex with SELENOF. Interacts with METTL23.
The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
Belongs to the glycosyltransferase 8 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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